In the past, researchers have attempted to do this with gene editing
tools like zinc fingers nucleases, but the process was too labor - intensive to be used on a large scale.
These approaches, which include exotic sounding
tools like zinc finger nucleases and CRISPR / Cas9, differ from more traditional ways reducing the impact of the HD mutation on cells.
Not exact matches
The variety of new
tools available for genetic manipulation now include lentiviral - based gene delivery, and gene editing using CRISPR / Cas9,
zinc finger nucleases (ZFNs) or transcription activator -
like effector nucleases (TALENs).
Zinc finger nucleases [1], [2], transcription activator -
like effector nucleases [3], [4] and homing meganucleases [5] have provided powerful
tools to induce targeted mutations in the form of small insertions or deletions derived from DNA break repair of nonhomologous end joining (NHEJ) or homologous recombination.
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