Sentences with phrase «topoisomerase inhibitors»

Last year the labs of Mark Zylka and Ben Philpot at the University of North Carolina at Chapel Hill discovered that a class of drugs called topoisomerase inhibitors reduces the expression of long genes.

Cancer Center investigators demonstrate that topoisomerase inhibitors induce programmed cell death in leukemia cells.

Although this class of compounds has shown efficacy in a variety of cancers, interest in developing new topoisomerase I inhibitors, indenoisoquinolines, are currently being evaluated in human patients as agents with improved drug stability and measurable blood levels.

«We only focused on a class of chemotherapy used to treat colon and breast cancer called topoisomerase I inhibitors.

Phase I Clinical Trial of VX - 970 in Combination with the Topoisomerase I Inhibitor Irinotecan in Patients with Advanced Solid Tumors

A class of anticancer compounds, called topoisomerase inhibitors, is shown by Cancer Center scientists to initiate antitumor responses in treatment - resistant cancers.

Also, a 2012 study published on the Medical Journal 3 Biotech shows that the anti-cancer compounds in mushrooms play a crucial role as a reactive oxygen species inducer, mitotic kinase inhibitor, antimitotic, angiogenesis inhibitor, topoisomerase inhibitor all leading to apoptosis (cell death) and eventually checking cancer cell proliferation (4).