Sentences with word «topotecan»

Researchers then used the anti-cancer drug topotecan to link elevated levels of Top1cc to the cell death and other problems seen in mice lacking Atm and Tdp1.

The new compound targets topoisomease I, an enzyme that is already exploited for cancer chemotherapy by topotecan and irinotecan.

Incorporating topotecan into front - line therapy of advanced localized retinoblastoma cures patients and improves survival of eyes with useful vision.

Indeed the Greenberg lab found that adding low doses of the drug topotecan to cultured cells lacking MeCP2 normalized levels of long genes.

There are three common drugs for advanced ovarian cancer: paclitaxel, cyclophosphamide, and topotecan.

«While FL118 is an analogue of irinotecan and topotecan, two FDA - approved cancer drugs that are also based on the naturally occurring compound camptothecin, our findings add further evidence that FL118 has novel mechanisms of action that may make it especially potent against solid tumors and especially effective as a well - tolerated, targeted therapy,» said Dr. Li, an Associate Professor of Oncology in the Department of Pharmacology and Therapeutics.

ATM - dependent activation of p53 is usually induced by many — if not all — types of DNA - damage drugs, including camptothecin compounds such as irinotecan and topotecan, leading the authors to conclude that FL118's mechanisms of action are distinct among camptothecin analogues.

While thousands of agents based on camptothecin have been synthesized, and two of these analogs — irinotecan and topotecan — have been approved for treatment of many solid - tumor cancers, these compounds typically are highly toxic to healthy cells, and not all of them have proven effective as anticancer agents.

In this study, patients began treatment with chemotherapy using cyclophosphamide and topotecan and the experimental monoclonal antibody hu14.18 K322A.

Dr. Wakelee also noted that previous work with drugs like bevacizumab and topotecan have shown similar promise to what this trial suggests with sunitinib, and little came of it.

Extending platinum - free interval with pegylated liposomal doxorubicin, topotecan, or gemcitabine does not improve overall survival among patients with recurrent ovarian cancer.

Investigators showed that the impact of Top1cc accumulation was strikingly similar whether the cause was topotecan or the loss of Atm and Tdp1.