Besides influencing the function of the microbiome, changes in bacterial genes also affect
total genome size, which can bias the estimation of the proportion of each gene in the sample.
Not exact matches
Finally, the synthetic
genomes were segmented at a window
size of 200kb into distinct genomic bins where the
total size of each gap annotation was tallied.
A complex technical challenge To put the huge
size of the bread wheat
genome into context, its constituent number of paired DNA bases, or nucleotides,
totals 17,000,000,000 base - pairs (17 Gb).
When microbiomes are studied using metagenomics — sequencing their
total DNA — differences in bacterial
genome size can bias the estimation of the proportion of each gene in the sample.
«Even though a microbial
genome is one - thousandth the
size of the human
genome, the
total number of microbial genes in [the human] body is much greater than human genes because you have so many different species,» says Weinstock.