Sentences with phrase «toxic cellular debris»
Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.
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The prize was for his work on autophagy, a kind of cellular housekeeping that helps clear the cell of damaged proteins and other potentially toxic debris.
These effects are evoked and sustained by: 1) endogenous and exogenous stress, 2) toxic and cellular debris factors; 3) decreased clearance of intracellular debris,... and 4) increased activation of NF - kB and inflammasomes.»