Sentences with phrase «toxic cisplatin»
The researchers are now testing new ways to decrease these side effects, including substituting paclitaxel (Taxol), which causes fewer side effects, for the highly toxic cisplatin.
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In the case of cisplatin - induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells» mitochondria.
In early studies on rabbits, the anticancer drug cisplatin, a simple but highly toxic chemical containing platinum, was added to Intradose CDDP.
«We found that pemetrexed combined with cisplatin is less toxic, well tolerated, and should be developed for further treatment of cervical cancer,» said gynecologic oncology specialist Dr. David Miller, Professor of Obstetrics and Gynecology and a member of the Harold C. Simmons Cancer Center.
«Given that pemetrexed combined with cisplatin may be less toxic than and as active as cisplatin plus paclitaxel and that it can be combined with bevacizumab, investigating the comparison of cisplatin - pemetrexed plus bevacizumab with cisplatin - paclitaxel plus bevacizumab would be the next appropriate step,» said Dr. Miller, who holds the Amy and Vernon E. Faulconer Distinguished Chair in Medical Science and the Dallas Foundation Chair in Gynecologic Oncology.