Sentences with phrase «toxic clumps»
The phrase "toxic clumps" refers to substances that have come together in a harmful or poisonous way, forming a clustered or grouped mass. Full definition
That leads the protein alpha - synuclein to build up and form toxic clumps in brain areas that control motor function.
scientificamerican.com
The antibodies most likely work by binding to infectious prions, preventing them from forming toxic clumps, he explains.
The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein build - up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps, researchers say.
The amyloid molecules in these cells formed small toxic clumps, amyloid oligomers, which were present even in individuals in their 20's and other normal young individuals.
The prions travelled to the animals» brains where they caused other proteins to misfold and form deadly, toxic clumps in the nervous system.
The pre-clinical study results show that squalamine prevents and eliminates α - synuclein build up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and builds up into toxic clumps, researchers say.
In Parkinson's disease, α - synuclein, a normal protein present within the nervous system, forms toxic clumps that damage and ultimately destroy the neurons in which they form.
Amyloid plaques are the toxic clumps of protein that cause damage to cells in the brains of people with Alzheimer's disease.
In July a team of neurologists at Brigham and Women's Hospital in Boston reported that a nasal spray containing the drugs cleared more than 80 percent of the toxic clumps in mice.
This could allow them to further probe the «toxic clumps or missing protein» question and understand which treatment strategies might be most successful.
In this study, the researchers demonstrated in a series of in vitro experiments that squalamine, a positively charged molecule with a high affinity for negatively charged membranes, could literally «kick off» α - synuclein from negatively charged membranes, where the protein binds, preventing the formation of the toxic clumps.