Sentences with phrase «toxic mutant huntingtin»
Note: these mice don't produce toxic mutant huntingtin protein.
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In humans, Huntington's is an inherited disease caused by a gene encoding a toxic protein, called mutant huntingtin, which causes brain cells to die.
Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin) that causes brain cells to die.
The mutant Huntingtin gene is thought to cause toxic levels of protein to aggregate in the brain.
Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin or mHTT).
Huntington's is an inherited disease caused by a gene encoding a toxic protein (mutant huntingtin) that causes brain cells to die.
Huntington's disease is caused by a gene encoding a toxic protein (mutant huntingtin or mHTT) that causes brain cells to die.
Given the adult onset and dysfunction and death of adult neurons characterizing HD, most studies have focused on the toxic effects elicited by mutant huntingtin in post-mitotic neurons.
«Huntington's — an inherited and fatal disorder that leads to problems with muscle coordination, cognition and personality — is characterized by the toxic buildup of a mutant form of the huntingtin protein in the brain,» explained Dr. Finkbeiner, who directs the Taube - Koret Center for Neurodegenerative Disease Research at Gladstone.