Sentences with phrase «toxicity at the high doses»

The fat soluble vitamins A and D can accumulate and cause toxicity at high doses over prolonged periods, so these must be monitored.

In addition to goitrogens, crucifers also contain substances called nitriles that can release cyanide into tissues and result in general toxicity at high doses.15 A 2004 study conducted in Japan suggested that massive doses of nitriles, doses that are impossible to obtain from food, would be required in order to result in toxicity.16 This study used behavioral endpoints such as restlessness to judge toxicity.

There is a risk of toxicity at high doses of leucine supplementation unless it is accompanied by the other branched - chain amino acids, isoleucine and valine:

Not exact matches

Widespread concern and public pressure — combined with growing science on arsenic's toxicity at low doses — should have spurred the U.S. Food and Drug Administration (FDA) and the cereal industry to take high - arsenic cereals off store shelves.

Additionally, I predict that at the completion of our study, despite the higher doses given per treatment in the experimental accelerated, hypofractionated RT arm, there will be no increased toxicity with this regimen.

«The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses,» writes Hollick, a professor of medicine, physiology and biophysics at Boston University School of Medicine.

«People have looked at the effects of nanoparticles on intestinal cells before, but they tend to work with really high doses and look for obvious toxicity, like cell death,» said Mahler.

Some magnetic resonance techniques can give information about the quantity and function of beta cells, he says, but they use a dose of manganese chloride that is at least 1 million times higher than the new PET technique, suggesting an advantage in lower toxicity.

The benzoxazine compounds were synthesized by altering the ring core structure, preventing toxicity even at high doses.

The application of ActD at high doses (> 800 nM) is limited due to its high toxicity through acting as a transcription blocker; however at low doses (10 - 100 nM) it induces p53 expression and is not highly toxic [13, 14].

However, because a fraction of colloidal silver may become silver salt, overconsumption of colloidal silver can still cause silver toxicity at very high doses.

Second, Warfarin, a vitamin K inhibitor, produces a toxicity profile almost identical to that of vitamin D, but does not increase serum calcium levels.81 Third, one group used vitamin D to produce calcium deposition in the kidneys of chickens at doses that did not lead to hypercalcemia.104 This finding is consistent with a case report of four post-menopausal women who were taking undetermined doses of vitamin D without their knowledge in the form of supplements that appeared to be contaminated with large amounts of vitamin D2: these patients had abnormally high vitamin D levels, three times the calcium in their urine as is normal, and appeared, albeit inconclusively, to have associated bone loss.

Melatonin is not associated with liver toxicity even at high doses (up to 20 mg / day) for prolonged periods of administration (up to 12 weeks) in both adults and children.

And numerous studies conducted to test the herbs» toxicity levels have shown that Tongkat Ali is safe to be consumed even at higher doses.

At low - moderate doses, something in a food can be quite healthy, even beneficial, but at very high doses we either plateau our efficacy or start to get into troublesome toxicitAt low - moderate doses, something in a food can be quite healthy, even beneficial, but at very high doses we either plateau our efficacy or start to get into troublesome toxicitat very high doses we either plateau our efficacy or start to get into troublesome toxicity.

Although selenium is generally considered safe at standard doses, very high dosage can cause selenium toxicity.

While little data about toxicity exists, lab animal studies have shown toxicity to the nervous system and liver at high doses.

Ivermectin toxicity Many dogs can tolerate the low dose required to prevent heartworms but when ivermectin is used to treat the many other parasitic infections in dogs it is used at much higher doses and the likelihood of toxicity increases.

Metronomic chemotherapy is a low dose at high frequency that lowers toxicity and is aimed at the tumor.

The side effects are related to liver toxicity, like ketoconazole, with the addition of ulcerative skin lesions and swelling of the legs at the higher dose.