Sentences with phrase «trabecular meshwork»
The phrase "trabecular meshwork" refers to a delicate network of tiny tissues located inside the eye. It acts like a drain, allowing fluid to flow out of the eye. Full definition
Still other researchers are working with RPB grants to promote optic nerve regeneration, to study changes in trabecular meshwork gene expression about a decade before risk of the disease starts going up, and to determine if abnormal blood flow is an important factor in causing glaucomatous optic nerve damage.
rpbusa.org
Project: Nanoengineered In Vitro Trabecular Meshwork ™ Model for Systematic Investigation of Aqueous Humor Outflow Resistance
The authors say that it's possible that the new trabecular meshwork cells generated from the stem cell treatment could eventually succumb to the same mechanisms that caused the fluid buildup in the first place, but further research is needed in that area.
«We believe that replacement of damaged or lost trabecular meshwork cells with healthy cells can lead to functional restoration following transplantation into glaucoma eyes,» said Keuhn, according to the press release.
Our lab has recently shown that endogenous TGF - Î ² 2 expression can be markedly and significantly attenuated in human trabecular meshwork cells and porcine anterior segments using the compound XJB -5-131, a novel antioxidant that targets a cell's mitochondria.
Trabecular meshwork cells help maintain proper intraocular pressure by serving as a filtering mechanism in the drainage of the eye's aqueous humor fluid.
When myocilin goes wrong, or «misfolds,» it makes fibrils that damage tissue called the trabecular meshwork that normally allows the fluid inside the eye to drain and relieve interior pressure.
«I think if we knew what this protein was doing in the trabecular meshwork, we would understand much more about glaucoma in general,» Lieberman said.
They already are exploring what these miRNA do in the trabecular meshwork that manages the continuous drainage of fluid made by the ciliary body to nourish and oxygenate a portion of the eye that has no direct blood supply.
TIGR is made by the eye's trabecular meshwork cells, which help regulate eye pressure by controlling the drainage of fluid from the eye as new fluid is produced.
When the posterior limbus and trabecular meshwork were examined (Figure 7A), the amount of fluorescence observed was qualitatively increased over that in which no wounding occurred (Figure 6B).
Other data obtained in this report (BrdU nitroblue tetrazolium staining by alkaline phosphatase and fluorescence due to fluorescein) would further suggest that putative stem cells are located in the posterior limbus between the peripheral endothelium and the trabecular meshwork.
The area of the trabecular meshwork and its surrounding posterior limbus in the human, however, showed considerable fluorescence indicative of cell division (Figure 6B).
Conclusions: It is suggested stem - like cells may be sequestered in a niche at the junctional region where the corneal endothelial cells and the trabecular meshwork come together.
In this report, no telomerase activity in the limbal region from Schwalbe's line to the trabecular meshwork was detected.
It supports the protective role of OPTN in the trabecular meshwork.
The cell infusion was found to regenerate the trabecular meshwork, which is a delicate patch of tissue that serves as a drain for the eyes to avoid a fluid buildup.
These tissues include the trabecular meshwork, which composes the drain of the eye and regulates intraocular pressure, and the optic nerve, which transmits visual information from the eye to the brain.
By reversing the damage to the trabecular meshwork, the authors write that the intraocular pressure (IOP) was significantly reduced and there was an improved eye fluid outflow, sustained for at least 9 weeks.
In most instances, OH results from impaired drainage of aqueous humor through the trabecular meshwork ™.
Summary: Patients with primary open - angle glaucoma (POAG) often present with chronically elevated intraocular pressure (IOP), the result of increased resistance to aqueous humor outflow through the trabecular meshwork.
The «angle» is also where the trabecular meshwork is located.
Carla J. Siegfried, MD Washington University School of Medicine, St. Louis, MO Funded by The Alcon Foundation Project: Pathological Alterations in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress
The eye fluid then flows out through a spongy tissue called the trabecular meshwork into a drainage canal.
Project: Pathological Alterations in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress
The trabecular meshwork, located near the cornea, is the spongy tissue that serves as the eye's primary drainage channel for aqueous humor.
TGF - Î ² 2 is known to elevate IOP by promoting increases in aqueous humor outflow resistance through the trabecular meshwork.
In the lamina cribrosa, like the trabecular meshwork we hypothesize that exosomes participate in the turnover of extracellular matrix and homeostatic signaling with cell neighbors, particularly in response to elevations in intraocular pressure / pulsations.
Dr. Keller was awarded the 2010 Shaffer Prize for Innovative Glaucoma Research for her research investigating the role of Glycosaminoglycans (GAGs) in fluid outflow resistance in the trabecular meshwork of the eye.
In this procedure, a tiny blade or laser is use to cut the trabecular meshwork (the spongy tissue that serves as the eye's primary drainage channel for aqueous humor).
Dr. Vranka's project studied Versican, a large proteoglycan that is known to interact with many other proteins also present in the trabecular meshwork, which is thought to be the primary contributor to outflow resistance.
By injecting molecules called short interfering RNAs directly into tissue known as the trabecular meshwork, researchers have been able to silence the action of disease - relevant genes.
RPB investigators have found that the normally spongy cells of the trabecular meshwork (TM) might be hardened by calcification in the eyes of people with glaucoma.
Elevated pressure in the eye can develop when the fluid produced within the eye, called vitreous humor, is obstructed as it drains through tissue the trabecular meshwork.
The outcome is an obstruction to the normal flow of aqueous humor through the trabecular meshwork, which can result in a sudden increase in intraocular pressure, quickly causing irreversible damage to the optic nerve leading to blindness [68,69].