Sentences with phrase «transcription coactivators»

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

In summary, our study in human NSCLC cells demonstrates that unphosphorylated STAT6 contributes to constitutive COX - 2 transcription via binding to the COX - 2 promoter in association with transcription coactivator p300.

Not exact matches

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

However, it is unclear whether this enhanced interaction selectively facilitates transcription of specific p53 target genes, including sestrins, or whether p53 serine18 phosphorylation also regulates specific target genes by altering interactions of p53 with other coactivators such as chromatin modifying enzymes.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

Interferon --LCB- gamma -RCB-- activated STAT - 1 -LCB- alpha -RCB- suppresses MMP - 9 gene transcription by sequestration of the coactivators CBP / p300

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.