Sentences with phrase «transcription factor nf»

Recent reports have suggested that both apoptosis and inflammation are regulated by the transcription factor NF - kappaB.

, Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF - κB

Curcumin inhibits activation of the transcription factor NF - kB, [5] which plays an important part in the regulation of the immune response to infection.

The cellular transcription factor NF - kB consists of two DNA - binding subunits of 50K and 65K and is believed to play an important role in stimulating transcriptional activation of HIV - 1 in latently infected T - cells

The activation dynamics of the transcription factor NF - κB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor — α (TNFα) but stable behavior when stimulated by lipopolysaccharide (LPS).

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

NF - κB is transcription factor that, among other functions, turns on genes involved in inflammation and immune response, and can be activated in the presence of pro-inflammatory cytokines.

Toll / IL -1 receptor domain - containing adaptor inducing IFN - β (TRIF) associates with TNF receptor - associated factor 6 and TANK - binding kinase 1, and activates two distinct transcription factors, NF - κB and IFN - regulatory factor - 3, in the Toll - like receptor signaling.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

A key transcription factor involved in expression of pro-inflammatory cytokines and senescence is Nuclear factor - kB (NF - kB) 24.

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].

Scientists aren't exactly sure, but in line with the study on NF - KappaB, they believe that glycine acts directly on inflammatory cells such as macrophages to suppress activation of transcription factors and the formation of inflammatory cytokines in the first place.

(In technical terms, NF - B is described as a proinflammatory transcription factor.)

Notably, ROS can directly or indirectly activate transcription factors such as NF - kB and AP - 1 that can promote inflammation.»

Daily meditation in distressed dementia decreases NF - kappa B signaling and increases interferon response factor transcription