Sentences with phrase «transcription factor expression»

The many regional differences in transcription factor expression that we uncovered may help explain this regional specificity, as has been documented already for labial and the Cu region.

A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.

Notably, in neurogenin - 2 transduced astrocytes we can see a similar sequence of transcription factor expression.

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

Furthermore, they found that the Sp7 transcription factor directly controlled gene expression of the Fgf ligands.

Each cell type can be distinguished based on its transcription factors, and a cell can in certain cases be directly converted from one type to another, simply by changing the expression of one or more transcription factors.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

In nonmutant mice, they found that the protein complex composed of Cbf - beta and the Runx2 transcription factor binds to the Wnt10b promoter to drive Wnt10b expression.

«Disrupting this circuit by targeting any of its individual components blocks the expression of these transcription factors and significantly impairs therapy - resistant prostate cancer,» said TSRI Research Associate Ji - Hak Jeong, the first author of the study.

Based on previous work, the researchers had reason to think it was controlled by transcription factors — proteins that control the expression of certain genes by binding to DNA at specific locations to induce (or block) the transcription of information from DNA to RNA.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

«Interestingly, because deltaFosB is a transcription factor, meaning that its job is to regulate the expression of other proteins, these findings led us to predict that the increased deltaFosB levels might be responsible for suppressing the production of proteins that are necessary for learning and memory,» Chin said.

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cells.

The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the University of Basel, have discovered how the transcription factor Gcn4, a protein that regulates the expression of many genes, extends the life of baker's yeast Saccharomyces cerevisiae.

KLF4 together with other reprogramming transcription factors is used in the lab to force the expression of genes in somatic cells (adult non-germline cells) in the development of iPSCs.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

Earlier work Weimbs conducted at UCSB had shown that the transcription factor called STAT6 is overly active in PKD, and he also recalled that STAT6 had been shown to drive the expression of pIgR in other organs.

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.

It does so by activating the transcription factor STAT3, which in turn inhibits expression of the miR - 34a gene by directly binding to it.»

Until this study, researchers weren't able to manipulate production of the different components independently of each other, since many of the transcription factors, proteins that bind to the plant's DNA and regulate gene expression, are redundant.

Center cells lost the expression of octamer - binding transcription factor 4 (OCT4) and epithelial cadherin (E-cadherin) faster than perimeter cells, which are critical to the development of heart tissue.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

Coincidently, the group observed increased expressions of SOX9, a chondrocytic transcription factor, and of COL2A1 and ACAN, two cartilage extracellular components, all of which are down - regulated in TD patients.

The master regulator transcription factors and super-enhancers work together to regulate the expression of critical genes, such as those responsible for cell identity.

The most common way to turn a gene on or off is by using proteins called transcription factors that bind to and regulate the expression of a specific gene.

We have suggested that this subtype of interneuron is defined by the expression of this transcription factor,» explains Mathieu Niquille, a researcher in the Department of Psychiatry at UNIGE's Faculty of Medicine.

Cortical neurogliaform cells come from this region that borders the third ventricle (middle, in black), marked by the expression of the transcription factor HMX3 (in red).

«Although this is true of many transcription factors, it has been difficult to develop therapeutics that directly target the Myc protein, an alternative approach may be to target the proteins that regulate Myc expression.»

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Expression of barley SUSIBA2 transcription factor yields high - starch low - methane rice, Nature July 22 (online), 2015, DOI: 10.1038 / nature14673

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.

Reference article: The transcription factor GATA6 enables self - renewal of colon adenoma stem cells by repressing BMP gene expression Gavin Whissell, Elisa Montagni, Paola Martinelli, Xavier Hernando - Momblona, Marta Sevillano, Peter Jung, Carme Cortina, Alexandre Calon, Anna Abuli, Antoni Castells, Sergi Castellvi - Bel, Ana Silvina Nacht, Elena Sancho, Camille Stephan - Otto Attolini, Guillermo P. Vicent, Francisco X. Real and Eduard Batlle Nature Cell Biology (2014) Doi: 10.1038 / ncb2992

In C. albicans, an isochromosome 5 can arise in response to fluconazole treatment and confers drug resistance because the left arm of Chr 5 encodes Erg11 (lanosterol 14α demethylase), the target of fluconazole, and Tac1, a transcription factor that activates expression of drug export pumps [15], [17].

The transcription factor Runx3 enhances the differentiation and survival of CD8 + resident memory T cells; enhancing Runx3 expression in responding T cells could lead to better therapies for infection and cancer.

We then infected these cells with two retrovirus encoding SOX2 and Ascl1, and you will see sometimes the images depicting the fluorescence, the reporter of fluorescence indicating the expression of the two transcription factors.

In this study, published in Nature 2010, Vierbuchen and colleagues showed that fibroblasts can be converted into neurons by false expression of defined transcription factors.

The serum response factor and a putative novel transcription factor regulate expression of the immediate - early gene Arc / Arg3.1 in neurons.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

But how can we induce astrocyte to NSC conversion without the ectopic expression of neurogenic transcription factors?

This, in turn, because the scientists did not know which DNA sequences are functional, and bind to the specific proteins called transcription factors that regulate gene expression.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

Extracellular Acidosis Stimulates NHE2 Expression through Activation of Transcription Factor Egr - 1 in the Intestinal Epithelial Cells.