Sentences with phrase «transcription factor identified»

Myocyte enhancer factor 2C, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)- enhanced mineralization.

Not exact matches

To see how the mutation affects alpha - synuclein production, the researchers identified two transcription factors that bind to the enhancer that carries this mutation.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

«Transcription factors distinguishing glioblastoma stem cells identified.»

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

The key regulator they identified were the RFX transcription factors.

The researchers used an example to demonstrate the mechanism: They identified the transcription factor STAT3, which regulates inflammatory processes and can promote tumor development, as a prominent target protein of one peroxiredoxin.

To understand defective disease process, investigators need to track where and how transcription factors bind to DNA to identify the differences between healthy and diseased cells.

The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells.

Under the supervision of Professor Jussi Taipale, researchers at Karolinska Institutet have previously identified most of the DNA words recognised by individual transcription factors.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

By studying Arabidopsis plants for which the genes for these transcription factors had been selectively knocked out, the group identified a single transcription factor that when inactive resulted in longer roots.

Some transcription factors already have been identified as playing a role in melanoma development.

The team identified a lncRNA, called NANCI, that regulates the critical transcription factor Nkx2.1.

An international consortium under the leadership of Prof. Dr. Thomas Laux, a biologist from the University of Freiburg, has identified the transcription factor WUSCHEL HOMEOBOX (WOX) 5 as the signal molecule, showing that it moves through pores from the cells inside the quiescent centre into the stem cells.

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability of immature neurons to develop into adult sensory neurons.

The researchers identified a transcription factor called POU6F2, which is found in developing nerve cells in the retina and corneal cells in mice.

We identified a protective mechanism that is controlled by the transcription factor ARNT, which effectively inhibits progression of chronic kidney injury by transcriptional induction of ALK3, the principal mediator of anti-fibrotic and pro-regenerative BMP signaling responses.

A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.

Researchers identify a network of a dozen transcription factors needed to maintain the pluripotent state of mouse embryonic stem cells.

Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.

One way is to identify transcription factors, and one way to identify transcription factors in microRNAs that can be used for reprogramming, is to screen for them through microarrays or RNA sequencing within the embryonic brain tissue.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

In this publication, Mergoud et al. identify UNC - 120 / SRF as the first conserved transcription factor that regulates the pace of muscle aging in a cell autonomous manner, downstream of the insulin / IGF1 receptor.

«This study identifies how the modification of the DNA structure affects the binding of transcription factors, and this increases our understanding of how genes are regulated in cells and further aids us in deciphering the grammar written into DNA,» study co-author Jussi Taipale from Karolinska Institutet in Sweden said in a statement.

Through these studies he has identified a new transcription factor and associated pathway that could yield new avenues for therapeutic intervention in SMA.

In this study, Mergoud et al. identify UNC - 120 / SRF as the first conserved transcription factor that regulates the pace of muscle aging in a cell autonomous manner, downstream of the insulin / IGF1 receptor.

For example, a research team last year used LINCS data to identify the role of a critical transcription regulator, heat shock factor 1 (HSF1), in cancer.

The GDDS laboratory was responsible for first identifying the transcription factor SOX10 as a key lineage - specific regulatory factor in melanocytes that is mutated congenitally in individuals with Waardenburg syndrome IV.

Evidence from mouse knockout models and human mendelian disorders suggest that these transcription factors have a function in determining cell identify in the developing breast.

ChIP - Seq is a powerful tool to study genetic regulation, because it enables one to accurately identify regions of DNA bound by specific proteins, such as transcription factors or RNA Polymerase II components.

Here, we identify three additional novel mutant alleles of the SHELL gene, which encode a type II MADS - box transcription factor, and determine oil yield via control of shell fruit form phenotype in a manner similar to two previously identified mutant SHELL alleles.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

Other researchers had identified a transcription factor called C / EBPα as another development trigger.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

We used a bioninformatics analysis to identify that miR - 181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP - induced neurite growth.

Their system was based on earlier studies in which Singh and his colleagues identified a transcription factor called PU.1 as a central genetic switch that triggers development of myeloid progenitor cells.

In last years, the «Stress and Cancer» laboratory has identified two new molecular players of the oxidative stress response, the miR - 200 family of microRNA and the transcription factor JunD.

Using our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with del1p36 that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation.

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

268/4: 45 Identifying the transcription factors mediating enhancer — target gene regulation in the human genome.

Measurements that are increasingly available range from those that identify transcription factor occupancy and initiation of transcription to long - lasting and heritable epigenetic marks such as DNA methylation.

Exploiting transcription factor binding site clustering to identify cis - regulatory modules involved in pattern formation in the Drosophila genome B.P. Berman, Y. Nibu, B.D. Pfeiffer, P. Tomancak, S.E. Celniker, M. Levine, G.M. Rubin, M.B. Eisen Proc Natl Acad Sci U S A (2002) 99:757 - 762

The first is identifying relevant transcription factors to reprogram stem cells, and the second is finding potential drugs with off - label benefits or adverse effects.

IRF8, a crucial transcription factor for pDC development and activation, was identified as a target of miR - 618.

Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downstream transcription factor network that specifies a lineage switch between sebocytes and SD cells.

Scientists from Massachusetts Eye and Ear have identified a new transcription factor involved in retinal neovascularization: Runt - related transcription factor 1 (RUNX1).