Sentences with phrase «transcription factor which»

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

The guilty protein is beta - catenin, a transcription factor which activates other genes.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

These include proteins which control important processes in the cells, for example the transcription factors which activate genes for the production of new proteins.

Not exact matches

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

When the enhancer is not mutated, the transcription factors bind to it, which suppresses SNCA.

Currently, enhancers can be identified through chromatin - based assays, such as ChIP - seq, which predict enhancer elements indirectly based on the enhancer's association with specific epigenomic marks, such as transcription factors or molecular tags on DNA - associated histone proteins.

They took a naturally occurring mitochondrial transcription factor called TFAM, which initiates protein synthesis, and engineered it to cross into cells from the bloodstream and target the mitochondria.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

Once inside the myofibroblasts, the virus downloads the transcription factors, which transform the cells into hepatocytes.

Spalax naturally have a variant in the p53 gene (a transcription factor and known tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.

The researchers used an example to demonstrate the mechanism: They identified the transcription factor STAT3, which regulates inflammatory processes and can promote tumor development, as a prominent target protein of one peroxiredoxin.

In addition, the total amount of a protein can be regulated by alternative splicing, which is illustrated in the current work by using the general transcription factor TBP (TATA - box binding protein) as an example.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

The scientists then moved on to study mice which had been genetically altered so that their hair cells lacked two of the RFX transcription factors.

By studying Arabidopsis plants for which the genes for these transcription factors had been selectively knocked out, the group identified a single transcription factor that when inactive resulted in longer roots.

These include a family of signaling molecules called protocaderins, which regulate neuronal development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in brain development.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genes.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

The transcription factors, which are proteins that control the flow of genetic information, generate an enzyme responsible for detoxifying harmful molecules, which accumulate under very bright light.

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

The study, which can be read in Nature Communications, shows the transcription factor family MYB3R prevents progression to the division stage (M phase) of the cell cycle in Arabidopsis, a small flowering plant that is a member of the mustard family.

We had started working on this more than a year ago, when we tried inserting four transcription factors, which regulate genes, into the skin cells.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

The switch, in turn, is flicked on by proteins called transcription factors, which activate certain genes in response to certain stimuli.

Retrotransposons are littered with transcription factor binding sites, which might be expected for entities that make their living by getting copied into RNA over and over again.

Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors.

It does so by activating the transcription factor STAT3, which in turn inhibits expression of the miR - 34a gene by directly binding to it.»

The second gene would then manufacture its corresponding transcription factor, which was designed to bind to and ratchet up the activity of the same gene that created it.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

Center cells lost the expression of octamer - binding transcription factor 4 (OCT4) and epithelial cadherin (E-cadherin) faster than perimeter cells, which are critical to the development of heart tissue.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

In 2003, Sun and colleagues had discovered a so - called transcription factor, which turns on genes involved in making starch.

In early work in Sweden, Jansson and his team investigated how distribution of sugars in plants could be controlled by a special protein called a transcription factor, which binds to certain genes and turns them on or off.

Coincidently, the group observed increased expressions of SOX9, a chondrocytic transcription factor, and of COL2A1 and ACAN, two cartilage extracellular components, all of which are down - regulated in TD patients.

By exposing muscle in vitro to a combination of metabolites, the researchers found that transcription factor nur77, which has recently been linked to lipid metabolism and glucose use, was upregulated (but had remained unchanged when exposed to only singular metabolites).

To find that gene, developmental biologist Deepak Srivastava of the University of Texas Southwestern Medical Center at Dallas and colleagues studied development of the mouse heart, in which a transcription factor called dHAND was known to turn on an array of crucial genes.

The approach helped to discover and nominate Lmx1A as a master regulator transcription factor of Group 4 tumors, which led to the identification of the likely Group 4 tumor cells of origin.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

The researchers identified a transcription factor called POU6F2, which is found in developing nerve cells in the retina and corneal cells in mice.

Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS / GATA / SOX) was found to have gradually switched from a «brake histone mark,» which suppresses transcription, to an «accelerator histone mark,» which activates transcription, while in the process of differentiating into the vascular endothelium.

Transcription factors determine which genes are active at what time and in which conditions and consequently have a critical role in organisms.

Transcription factors — both natural and artificial — determine which genes are translated into proteins inside cells.

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.