Sentences with phrase «transcription factors at»

Previous whole - genome chromatin immunoprecipitation analyses have identified a wide set of Oct4 target genes [6], [28], as well as describing co-occupancy of Oct4 and other transcription factors at many of these genes [6].

The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).

Our bodies have about 1,600 known transcription factors at work within our genome.

Not exact matches

«But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease.»

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

Ko - Ferrigno started a Ph.D. in molecular biology at Northwestern University in Chicago, working on the so - called GATA transcription factors.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

Under the supervision of Professor Jussi Taipale, researchers at Karolinska Institutet have previously identified most of the DNA words recognised by individual transcription factors.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

Based on previous work, the researchers had reason to think it was controlled by transcription factors — proteins that control the expression of certain genes by binding to DNA at specific locations to induce (or block) the transcription of information from DNA to RNA.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genes.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

Only some of the plant's 30,000 genes are active in a given root cell at a given time, thanks to proteins called transcription factors that turn genes on and off as needed.

The researchers led by Prof. Mihaela Zavolan and Prof. Anne Spang, both at the Biozentrum of the University of Basel, have discovered how the transcription factor Gcn4, a protein that regulates the expression of many genes, extends the life of baker's yeast Saccharomyces cerevisiae.

As an undergraduate biology major at Johns Hopkins University in Baltimore, Maryland, Niyogi focused on molecular and cell biology and thought about immunology or transcription factors as a potential field of study.

Earlier work Weimbs conducted at UCSB had shown that the transcription factor called STAT6 is overly active in PKD, and he also recalled that STAT6 had been shown to drive the expression of pIgR in other organs.

A few more years to go On the West Coast, Brady's lab is also looking at transcription factors in sorghum.

«What was really cool about this research was we've known for a long time that a lot of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director of plant systems biology at the Joint BioEnergy Division, a part of the Department of Energy.

The team generated a profile of open and closed areas in eight stages of T - cell development and found an abundance of the transcription factor TCF - 1 at regions along the genome that were open at the earliest stages of development.

In addition to looking at transcription factors, researchers have studied the genes that code for the enzymes responsible for building up the plant's biomass.

Solving a puzzle of plant manipulation Rather than try to isolate single genes related to secondary cell wall production, the researchers looked at the function of hundreds of transcription factors working within the root xylem's regulatory network.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

«We do these kinds of genetic studies all the time — looking at transcription factors and what they do.

To find that gene, developmental biologist Deepak Srivastava of the University of Texas Southwestern Medical Center at Dallas and colleagues studied development of the mouse heart, in which a transcription factor called dHAND was known to turn on an array of crucial genes.

A transcription factor will bind only at 1,000 places, or maybe the biggest bind is at 50,000 specific places across the genome.

«I think this is going to be a fairly complex thing to work out,» Reeves says, adding that Ets2 encodes a transcription factor that influences the activity of at least 200 other genes.

We have suggested that this subtype of interneuron is defined by the expression of this transcription factor,» explains Mathieu Niquille, a researcher in the Department of Psychiatry at UNIGE's Faculty of Medicine.

Overcoming this challenge, researchers at Cincinnati Children's Hospital Medical Center discovered a small molecular compound that successfully blocks a transcription factor and its pro-inflammatory and hyper - mucous activity in asthma.

Transcription factors determine which genes are active at what time and in which conditions and consequently have a critical role in organisms.

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.

OPC differentiation was selectively blocked by bHAf in a maturation - dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4 / TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

FoxO3 constraint of OPC maturation was bHAf dependent, and involved interactions at the FoxO3 and MBP promoters with the chromatin remodeling factor Brg1 and the transcription factor Olig2, which regulate OPC differentiation.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

The variant allele disrupts predicted binding sites for two transcription factors (MEF2C and CDX2) and creates possible binding sites for at least two others.

For example, his group looked at specific signaling pathways and transcription factors expressed in their pre-HSCs.

In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research group continued to study the regulation of interferon genes and discovered the interferon - regulatory - factor family of transcription factors.

Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.

Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

To this end, we are developing a new multi-scale live imaging approach to characterize nuclear organization dynamics at the single cell level based on the simultaneous characterization of both the local dynamics of RNA polymerases and transcription factors and the large scale behavior of chromatin.

In the work published in Cell, the scientists at Karolinska Institutet describe DNA sequences that bind to over 400 such proteins, representing approximately half of all human transcription factors.

Transcription factors are expressed (or made) at different levels in different cell types, and control what genes are expressed in every cell, making sure, for example, that a liver cell remains a liver cell and does not become a neuron.

He received his Ph.D. in Molecular Microbiology at Tufts University in Boston, writing a thesis on transcription factors that regulate the morphological switches of the pathogenic yeast Candida albicans.

Working with Nancy Cox, PhD, professor of medicine and human genetics and section chief of genetic medicine at the University of Chicago, Bell discovered mutations in the genes for glucokinase and for three transcription factors that cause an early - onset form of diabetes called maturity - onset diabetes of the young.

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

«Transcription factors have to stick together, or else the other one goes and gets into trouble,» says first author Luis Luna - Zurita, PhD, a postdoctoral fellow at Gladstone.

If one of the proteins was absent, at times the other transcription factors would go rogue, binding to places on the genome where they were not supposed to be.

Our colleagues at Gladstone are using this knowledge to search for small molecules that can affect gene regulation and reverse some of the problems caused by the loss of these transcription factors.»