Sentences with phrase «transcription factors called»

After much experimentation with multiple combinations, the researchers found that adding two more signals to the mix — transcription factors called ISL1 and LHX3 — turned the skin cells into spinal cord motor neurons in about 30 days.

These include a family of signaling molecules called protocaderins, which regulate neuronal development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in brain development.

They took a naturally occurring mitochondrial transcription factor called TFAM, which initiates protein synthesis, and engineered it to cross into cells from the bloodstream and target the mitochondria.

When blood flow and oxygen levels are low, a transcription factor called hypoxia - inducible factor (HIF) triggers the production of a chemical called VEGF.

Additionally, these sites were close to sites where another transcription factor called Runx1 was landing.

After receiving a signal that tells a transcription factor called GABP to bind the Terf2 gene.

More specifically, how a genetic transcription factor called hypoxia - inducible factor 1 (HIF - 1) helps our bodies adapt to low - oxygen environments, and how modifying that factor could help treat anemia and cancers.

Earlier work Weimbs conducted at UCSB had shown that the transcription factor called STAT6 is overly active in PKD, and he also recalled that STAT6 had been shown to drive the expression of pIgR in other organs.

To find that gene, developmental biologist Deepak Srivastava of the University of Texas Southwestern Medical Center at Dallas and colleagues studied development of the mouse heart, in which a transcription factor called dHAND was known to turn on an array of crucial genes.

The initial formation of long - term memory requires a chemical called brain - derived neurotrophic factor, while subsequent recall depends on a transcription factor called Zif268.

The researchers identified a transcription factor called POU6F2, which is found in developing nerve cells in the retina and corneal cells in mice.

RCM - 1 treatment removes a transcription factor called FOXM1 (shown in green) from the nucleus of cells (blue) to the cell cytoplasm.

A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.

Other researchers had identified a transcription factor called C / EBPα as another development trigger.

JAK2 is a kinase and similar to insulin activating downstream kinases, and leptin here is activating a downstream kinase called JAK2; JAK2, in turn, recruits a transcription factor called STAT3.

Their system was based on earlier studies in which Singh and his colleagues identified a transcription factor called PU.1 as a central genetic switch that triggers development of myeloid progenitor cells.

Under non-stress conditions a transcription factor called NRF2 is sequestered in the cytosol by another protein called Keap1.

Not exact matches

The Cincinnati Children's research team has discovered a new clue about how the virus does this, a process that involves tiny proteins called transcription factors.

They noted that Tregs generally had high levels of a protein called Helios, a transcription factor that helps switch genes on and off.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

Ko - Ferrigno started a Ph.D. in molecular biology at Northwestern University in Chicago, working on the so - called GATA transcription factors.

The scientists have found what researchers call a «transcription factor,» called ROC40.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

DNA binding proteins called transcription factors are required for maintaining cell identity.

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

Genes become more or less active at the touch of proteins called transcription factors, each of which can influence hundreds or thousands of other genes.

The specificity of this regulation originates in the binding interactions between special regulatory proteins, called transcription factors (TFs), and short regulatory sequences on the DNA, called binding sites.

The team identified a lncRNA, called NANCI, that regulates the critical transcription factor Nkx2.1.

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

Only some of the plant's 30,000 genes are active in a given root cell at a given time, thanks to proteins called transcription factors that turn genes on and off as needed.

The gene codes for a type of protein called a transcription factor.

The switch, in turn, is flicked on by proteins called transcription factors, which activate certain genes in response to certain stimuli.

In the early 2000s, they injected mouse skin cells with between four and seven pieces of protein called transcription factors.

Perhaps the most valuable scraps in the transposable element junk heap are bits of DNA called transcription factor binding sites.

Those transcription factors are alerted to infection by an immune system chemical called interferon gamma.

Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors.

In 2003, Sun and colleagues had discovered a so - called transcription factor, which turns on genes involved in making starch.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

In early work in Sweden, Jansson and his team investigated how distribution of sugars in plants could be controlled by a special protein called a transcription factor, which binds to certain genes and turns them on or off.

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

The growth of cancer cells is spurred by a family of transcription factors, called E2Fs.

Experiments in mice suggested an important role in long - term memory for CREB, one of many so - called transcription factors, proteins that switch genes on and off.

Instead, the stem cells» program involved just 16 interactions between 12 proteins, called transcription factors, and three environmental inputs, in this case provided by chemicals in the lab.

«Our research revealed how small RNA molecules can work with other cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.

While my husband was on call, and even when he wasn't, I buried myself in transcription factors that control developmental genes.

Two enzymes in the neurons activate proteins called transcription factors that turn on genes.

The most common way to turn a gene on or off is by using proteins called transcription factors that bind to and regulate the expression of a specific gene.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.