Sentences with phrase «transcription factors involved»

PAX6, OTX2 and MITF, transcription factors involved in RPE cell development, were localised in the nucleus, whilst RLBP1, PMEL17, and BEST1 were expressed cytoplasmically.

For example, sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail).

What's important about the discovery is that MER41's bits and pieces include binding sites for transcription factors involved in fighting infections.

A key transcription factor involved in expression of pro-inflammatory cytokines and senescence is Nuclear factor - kB (NF - kB) 24.

MyoD is normally only expressed in skeletal muscle, and it was later found to be a transcription factor involved in the differentiation of muscle cells and also a very early marker of muscle cell fate commitment.

The other major transcription factor involved in IL - 22 production is the aryl hydrocarbon receptor (AHR), which is important not only for Il22 expression in ILC3s [28], but also for the development of ILC3s from immature precursors [29].

For this latest study, published today (August 6) in Cell Stem Cell, Deng's team screened for compounds that would promote the efficiency of a transcription factor involved in neuronal conversion.

Transcription factor involved in the induction of oxygen regulated genes.

Scientists from Massachusetts Eye and Ear have identified a new transcription factor involved in retinal neovascularization: Runt - related transcription factor 1 (RUNX1).

Typically, a major transcription factor involved in the expression of detoxification genes known as Nrf2 remains in a dormant state in the body.

Not exact matches

The Cincinnati Children's research team has discovered a new clue about how the virus does this, a process that involves tiny proteins called transcription factors.

Detecting and tracking the activities of these transcription factors took years of work involving dozens of laboratory and computational experts.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

Their work elucidates a dynamic, two - step mechanism in females whereby B cells lacking the markers of X chromosome inactivation regain these modifications during B cell activation, in a process involving the transcription factor YY1.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

«What was really cool about this research was we've known for a long time that a lot of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director of plant systems biology at the Joint BioEnergy Division, a part of the Department of Energy.

The researchers predicted that if they removed this viral DNA from the cell, the transcription factors would not function properly, potentially disrupting genes involved in the innate immune response.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

In 2003, Sun and colleagues had discovered a so - called transcription factor, which turns on genes involved in making starch.

Instead, the stem cells» program involved just 16 interactions between 12 proteins, called transcription factors, and three environmental inputs, in this case provided by chemicals in the lab.

The STAT transcription factors are involved in the development of many forms of cancer.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

When a given gene needs to be transcribed to create new proteins, its promoter region must be unwrapped from the nucleosome so that it can be accessed by the factors involved in initiating the transcription process.

FoxO3 constraint of OPC maturation was bHAf dependent, and involved interactions at the FoxO3 and MBP promoters with the chromatin remodeling factor Brg1 and the transcription factor Olig2, which regulate OPC differentiation.

NF - κB is transcription factor that, among other functions, turns on genes involved in inflammation and immune response, and can be activated in the presence of pro-inflammatory cytokines.

We are investigating the roles of various transcription factors, kinases, and molecules involved in intracellular vesicular traffic in order to understand the differentiation of Vα14 iNKT cells.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

Upregulated genes clustered into at least 7 functional groups, including immediate early genes or transcription factors, cell - cycle related genes, stress - responsive protein genes, cell signaling protein genes, cell adhesion and cell surface protein genes, genes involved in translation and protein turnover, and genes encoding metabolic proteins.

The splicing factor proline - glutamine rich (SFPQ / PSF) is involved in influenza virus transcription.

We want to understand how different RFX transcription factors are required for ciliogenesis control and how they are involved in ciliary specialization in mouse tissues.

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

This pathway involves the transcription factor Tbx1, heterozygosity of which causes cardiac defects associated with DiGeorge syndrome.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

The mechanism of p21waf1 / cip1 induction caused by these factors often involves the action of corresponding transcription factors on the p21waf1 / cip1 promoter (17).

The researchers found that portions of the FTO gene were involved in switching on a promoter of IRX3, which encodes a transcription factor and is highly conserved in mice, zebrafish, and humans.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Once again, the genes that are subject to HAR2 regulation are still unclear, although GBX2, a transcription factor that controls proper expression of genes involved in embryo morphogenesis, is one promising candidate.

It's actually a very important transcription factor that's regulated by insulin, and this is involved in activating genes involved in fatty acid synthesis and so - called lipogenesis, which is synthesizing new lipids and this is, therefore, important in lipid metabolism.

Amphimedon lacks Hox genes and some other transcription factor subfamilies that are involved in specifying and patterning bilaterian nervous systems and body plans13, 14,27,36,37.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

Amphimedon possesses homologues of bilaterian proteins involved in nervous system development (for example, elav - and musashi - like RNA - binding proteins, neural transcription factors), pre - and post-synaptic organization (for example, Discs large) 42, endogenous and exogenous signalling (for example, G - protein - coupled receptors (GPCRs)-RRB-, and neuroendocrine secretion, although bilaterian peptide hormones are not detected (Supplementary Note 8.9).

Given the methodologies used in 2003, versus what's being used today, even without knowing more, it would seem unlikely that the patent could be «formidable,» especially if it involves any retroviral integration of transcription factors.

While it is possible to induce atherosclerosis in some mice, it is important to realize that the presence of cholic acid can influence transcription factors controlling genes involved with regulating lipoprotein metabolism and inflammation, both of which are important in the development of atherosclerosis (16, 17), and can also promote gallstones in certain mouse strains (18, 19).

Exploiting transcription factor binding site clustering to identify cis - regulatory modules involved in pattern formation in the Drosophila genome B.P. Berman, Y. Nibu, B.D. Pfeiffer, P. Tomancak, S.E. Celniker, M. Levine, G.M. Rubin, M.B. Eisen Proc Natl Acad Sci U S A (2002) 99:757 - 762

104 Several hormetic response pathways have been identified involving enzymes (kinases and deacetylases including Sirtuins), transcription factor - regulation the expression of several major categories of proteins including chaperones, antioxidant enzymes and growth factors.

Activation of the insulin receptor leads to sequential activation of a number of protein and lipid kinases, including the serine / threonine kinases Akt1 and Akt2, which not only stimulate mTOR and thus downregulate autophagic protein catabolism (and thus cysteine supplies), but elicit phosphorylation (inhibition) of FOXO1, a transcription factor that induces expression of proteins involved in both of the proteolysis recycling pathways: the autophagic / lysosomal pathway and the ubiquitin - proteasomal pathway.