Sentences with phrase «transcription factors like»

For example, enterolactone made from flaxseed lignans has been shown to be an estrogen agonist (promoting estrogen production, through increased formation of transcription factors like ER - alpha and ER - beta), as well as an estrogen antagonist (working against estrogen production, through inhibition of enzymes like estrogen synthetase).

Calling on transcription factors like NRF - 1 for damage control.

Transcription factors like MYCN work by summoning certain «co-factor» proteins to attach themselves to specific sections of DNA.

«Recent studies have shown that when transcription factors like MYC are mutated or overabundant, they can have a cancerous effect.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

Not exact matches

Adding seven transcription factors — proteins that switch on genes — the team then converted the IPSCs into immature HSC - like cells.

M. J. Bertram et al., Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor - like genes.

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

The genes — Oct 3/4, Sox2, c - Myc and Klf4 — are molecular switches called transcription factors, which activate other genes in series like a power strip.

They found that the combination of the transcription factors Brn3a plus Ngn1, or Brn3a plus Ngn2, reprogrammed a significant percentage of the embryonic mouse fibroblasts into what looked — and acted — like mature DRG - type sensory neurons.

Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell - like state where they can continue to proliferate and can later differentiate into various cell types.

Toll / IL -1 receptor domain - containing adaptor inducing IFN - β (TRIF) associates with TNF receptor - associated factor 6 and TANK - binding kinase 1, and activates two distinct transcription factors, NF - κB and IFN - regulatory factor - 3, in the Toll - like receptor signaling.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell - like state by introducing combinations of four transcription factors.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

Insulin - like growth factor - I — forkhead box O transcription factor 3a counteracts high glucose / tumor necrosis factor - α - mediated neuronal damage: Implications for human immunodeficiency virus encephalitis.

Distinct transcription factor networks predicate different tumor identities, corresponding to sympathetic noradrenergic or mesenchymal / neural - crest cell like identities.

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

The Wnt target gene encoding the transcription factor Achaete scute - like 2 controls the fate of the intestinal stem cell (26).

TCF - 1 is like an icebreaker ship that initially opens the ice (condensed, closed chromatin) and keeps a path available for other ships (other transcription factors that work in later stages of development) to steam through the now - open water (unwound chromatin).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

This adaptive program is largely controlled by two proteins: Kelch like - ECH - associated protein 1 (Keap1) and the transcription factor NFEL2L2 (Nrf2).

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

In vitro, ES cells can generate PrEn - like cells either in response to LIF withdrawal [24] or through forced expression of the transcription factors Gata4 or Gata6 [25], [26].

Amphimedon possesses homologues of bilaterian proteins involved in nervous system development (for example, elav - and musashi - like RNA - binding proteins, neural transcription factors), pre - and post-synaptic organization (for example, Discs large) 42, endogenous and exogenous signalling (for example, G - protein - coupled receptors (GPCRs)-RRB-, and neuroendocrine secretion, although bilaterian peptide hormones are not detected (Supplementary Note 8.9).

Variant of transcription factor 7 - like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Chlamydomonas reinhardtii encodes a single sigma70 - like factor which likely functions in chloroplast transcription

Like transcription factors, these genes turn on other stem cell genes and turn off those associated with different cell types.

Clostridium botulinum produces a transcription factor that can aggregate and self - propagate a prion - like form, leading to genome - wide changes in gene expression in E. coli, according to a study.

Structure of an MmyB - like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.

Recently, our lab has discovered that a member of Kruppel - like family of transcription factors, KLF9, regulates bortezomib - induced apoptosis in MM cells.

«There are multiple interactive pathways and molecular mechanisms by which CR (calorie restriction) and IF (intermittent fasting) benefit neurons including those involving insulin - like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator - activated receptors.

Ortiz, Lourdes, et al. «Transcriptional control of the forkhead thyroid transcription factor TTF - 2 by thyrotropin, insulin, and insulin - like growth factor I.» Journal of Biological Chemistry 272.37 (1997): 23334 - 23339.

The incredible ability of curcumin to promote various pathways like gene transcription factors, inflammatory cytokine pathways and various growth factors means that it has been studied for the many potential benefits for skin conditions like psoriasis, skin cancers, dermatitis, acne, wound healing and even keloid scars.

Insulin inhibits transcription of the human gene for insulin - like growth factor - binding protein - 1.