Sentences with phrase «transcription factors pathways»

The goal of this research is to provide clinicians and researchers with useful information on the function of transcription factor pathways in immunophenotypically defined populations.

Her current research focuses on developing clinical applications for imaging flow cytometry, with special attention to transcription factor pathways.

She obtained her Ph.D. from Ulster University in Northern Ireland, United Kingdom, studying the activity of nuclear - receptor transcription factor pathways in cancer.

Not exact matches

Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

Modeling and experiments show how a key transcription factor uses biochemical feedback in two separate pathways to trigger either sustained or transient inflammation.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

OPC differentiation was selectively blocked by bHAf in a maturation - dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4 / TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT.

Ellen V. Rothenberg and Susan B. Ward report that the interleukin - 2 (IL - 2) transcriptional apparatus integrates multiple types of biochemical information in determining whether or not the gene will be expressed, using multiple diverse transcription factors that are each optimally activated or inhibited by different signaling pathways.

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].

For example, his group looked at specific signaling pathways and transcription factors expressed in their pre-HSCs.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.

Molecular genesis of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK); microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).

In this representation, signal is coming from signalling pathways (upper part of the figure), where signalling receptors binding a ligand transmit their signal to enzymes and transcription factors.

β - catenin, a transcription factor, has been known to crosstalk with several developmental pathways [28] and is reported to play a role in DNA damage repair [29, 30].

This pathway involves the transcription factor Tbx1, heterozygosity of which causes cardiac defects associated with DiGeorge syndrome.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

If brain tumours are driven by neural stem cells with faulty developmental pathways, these transcription factors could potentially be good drug targets.

Boldrini says that future research on the ageing brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

Through these studies he has identified a new transcription factor and associated pathway that could yield new avenues for therapeutic intervention in SMA.

Activation of these pathways further leads to the activation of multiple transcription factors, pro- and antiapoptotic proteins, cell cycle check point proteins, etc. [4, 6, 8].

«Looking at gene expression, the ketogenic diet suppressed the longevity - related TOR pathway and insulin signaling and up - regulated the fasting - related transcription factor PPAR - alpha, a master regulator that helps the body more efficiently metabolize fat.»

May 25, 2000 Different levels of transcription factor coax immune cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the fates of developing cells.

One to two days before this layer was established, a CWI pathway transcription factor, Rlm1, was activated in a separate band of cells underneath the cells that would later sporulate.

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Mechanistically, decitabine acted synergistically with chidamide to enhance the interaction of KMT2D with transcription factor PU.1, regulated H3K4me - associated signaling pathways, and sensitized T - lymphoma cells to chidamide.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

The transcription factors specific to these pathways are also metazoan - specific (Tcf / Lef, Smads, CSL, Gli), whereas the cytosolic signal transducers generally have more ancient origins.

We used a bioninformatics analysis to identify that miR - 181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP - induced neurite growth.

Amphimedon also has fewer ligands and receptors in each pathway compared to eumetazoans (three Wnt and two Fzd, eight TGF - β ligands and five TGF - β receptors, one Notch and five Deltas)(Supplementary Note 8.5), as observed for many transcription factor families.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

Components of the major metazoan developmental signalling pathways, as well as classes of developmental transcription factors, are mostly present in Amphimedon and absent from Monosiga and other non-metazoan genomes13, 14,16,27,29, suggesting that ontogenetic development, including primary germ cell formation (Supplementary Note 8.4), originated on the metazoan stem3, 11,12.

Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes.

This finding suggests that extrinsic signaling pathways may lie upstream of the network of known transcription factors that regulate pluripotency.

These results indicate that the signaling pathways for the two types of IFN and double - stranded RNA share common components or that their function depends on common enzymes or transcription factors.

More recently, Drs. Goldstein and Brown discovered the SREBP family of membrane - bound transcription factors and the elucidation of the proteolytic pathway by which the SREBPs become activated to regulate lipid metabolism.

The FunGenES database provides such a template with a number of tools including Animation of KEGG Pathways, Expression Waves, Time Series, Specific Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene names and IDs.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.

104 Several hormetic response pathways have been identified involving enzymes (kinases and deacetylases including Sirtuins), transcription factor - regulation the expression of several major categories of proteins including chaperones, antioxidant enzymes and growth factors.

Activation of the insulin receptor leads to sequential activation of a number of protein and lipid kinases, including the serine / threonine kinases Akt1 and Akt2, which not only stimulate mTOR and thus downregulate autophagic protein catabolism (and thus cysteine supplies), but elicit phosphorylation (inhibition) of FOXO1, a transcription factor that induces expression of proteins involved in both of the proteolysis recycling pathways: the autophagic / lysosomal pathway and the ubiquitin - proteasomal pathway.

Peroxisome proliferator - activated receptors (PPAR) are a family of transcription factors induced by various ligands that act as anti-inflammatory agents by interfering with inflammatory signaling cascades, including the NFκB pathway.

«There are multiple interactive pathways and molecular mechanisms by which CR (calorie restriction) and IF (intermittent fasting) benefit neurons including those involving insulin - like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator - activated receptors.

The control of both glycolysis and lipogenesis by one transcription factor shows the close relation between these pathways.

The incredible ability of curcumin to promote various pathways like gene transcription factors, inflammatory cytokine pathways and various growth factors means that it has been studied for the many potential benefits for skin conditions like psoriasis, skin cancers, dermatitis, acne, wound healing and even keloid scars.