Sentences with phrase «transcription factors tested»

Of 12 transcription factors tested, only SOX2 switched fully differentiated, adult astrocytes to an earlier neuronal precursor, or neuroblast, stage of development, Dr. Zhang said.

Not exact matches

To test potential brain repair strategies, Berninger and Magdalena Götz of Ludwig - Maximilians University Munich delivered transcription factors into the cerebral cortex of adult mice three days after traumatic injury.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

We combined a behavioral test for magnetic compass orientation in mole rats and immunocytochemical visualization of the transcription factor c - Fos as a marker of neuronal activity.

But without any neuromorphology, thus we tested co-expression of SOX2, another transcription factor, which figures prominently amongst the Yamanaka reprogramming cocktail, but it's also well - known for its role in neuro stem cells.

In the next set of experiments, they engineered DNA bubbles into the DNA that varied between 3 and 12 base pairs and tested what size bubble would allow transcription to proceed in the absence of TFIIH, the basal or general transcription factor they implicated in forcing these DNA bubbles open.

We are currently testing the hypothesis that these transcription factors form a genomic regulatory network, and disruption of that network by mutation destabilizes gene expression programs, contributing to malignancy.

The project will test the hypothesis that the SOXC transcription factors have key roles in these cells, similar to those of SOX2 in pluripotent stem cells.

«We want to test the direct role of these transcription factors in the development of aggressive disease and response to chemotherapy.

Furthermore, IPA allows testing for significant enrichment of targets of specific transcription factors.