Sentences with phrase «transcription of a gene very»

Blau's group found that the daily changes in Rho1 activity are controlled by rhythms in transcription of a gene very similar to human Puratrophin - 1.

Not exact matches

He adds that the abundance of transcripts that overlap each gene suggests that the very term «gene» should mean something different inside the cell nucleus, where transcription takes place, than outside of it, where finished proteins go.

This is believed to be true given the results of previous RNA - seq experiments (1, 4, 5) along with a belief that the odds are very low that Cas9 would have an off - target that lands in the promoter of another gene, thereby driving aberrant transcription.

A third, more basic, project in our lab concerns the transcription and splicing of very large mammalian genes.

We have recently shown that transcription proceeds rapidly and efficiently through these genes and that splicing of the very long introns found in such genes is also efficient.

A few receptor genes have more than 8 different isoforms (38 VRs and 10 ORs), however in most of these cases this is due to the presence of several transcription start sites (TSS) or exons that differ in length by just a few nucleotides, so several of the final transcripts differ only very slightly (Figure S7B).

The algorithm can also accurately predict the effect of mutations on gene expression even for very low - affinity binding sites — regions in the genome where transcription factors bind to DNA, but do so in hard - to - detect ways.

The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a member of the family of transcription factors that regulate the expression of genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....