Sentences with phrase «transcription of these genes in»

«It's possible that microRNAs go into the bloodstream and affect the potential transcription of these genes in the sperm,» says Brian Dias at Emory University in Atlanta, Georgia, who led the work in mice.

STAT3 (signal transducer and activator of transcription 3) is a protein that activates the transcription of genes in response to IL - 6, a signaling protein released by cells in response to injury and inflammation.

Not exact matches

We can compare the diverse tasks performed by a colony to the many proteins generated by gene transcription, to various cell types of a developing embryo, or to the firing patterns of neurons in the brain.

The epigenetic impairments reflect changes that increase accessibility of chromatin, a process that enhances gene transcription, suggesting the impairments play an important role in addiction behavior.

These included sites involved in regulating gene activity during brain development and initiating the transcription of genes.

PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair and signaling.

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manneIn all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent mannein a concentration - dependent manner.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

«Our lab took part in analysing the group of RNA or transcriptome, that results from transcription, the process by which the instructions in the genes are read.

Based on the transcript sequences, the researchers identified 1,437 new promoters — short DNA sequences where transcription begins — in or between genes, on top of the 1,730 promoters they knew of.

Project members also catalogued sequences that mark areas where DNA unwinds from the round histone proteins that maintain the shape of chromosomes, allowing the cell's transcription machinery to activate genes in those areas.

In this way the binding of the DNA to the corresponding nucleosome is changed so that the DNA for example becomes accessible for transcription enzymes and activates a particular gene.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse.

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

In Class I engagement, Sox9 binds to the genome indirectly via the basal transcriptional complex, regulating transcription of genes for basal cell activities.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

In Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activitieIn Class I engagement, Sox9 binds indirectly to the DNA and regulates the transcription of genes involved in basal cell activitiein basal cell activities.

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related geneIn Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genein a high level of transcription of cartilage - related genes.

In the paper, the researchers illustrate how it could influence proteins that activate the transcription factors that transcribe major bone - related genes to drive bone formation — showing a link between metabolite usage and activation of transcription factors.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtIn addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growtin the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth.

In Class II engagement, it binds directly to the DNA in multiple locations and activates transcription of cartilage - related geneIn Class II engagement, it binds directly to the DNA in multiple locations and activates transcription of cartilage - related genein multiple locations and activates transcription of cartilage - related genes.

Alternative splicing was long considered a rare hiccup during transcription, but researchers have concluded that it may occur in half — some say close to all — of our genes.

The oxidation status of STAT3, in turn, determined how efficiently the transcription factor regulates gene activity.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

Disease processes often begin with mutations in the transcription factor, or in the DNA they bind to inside the nucleus of cells to regulate the complex interplay of genes needed for a healthy functioning body.

During this time, transcription — the conversion of gene «recipes» encoded in DNA to mRNA, the messenger that carries the recipe to the cell's protein - making machinery — is completely shut off.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

He will promote high - throughput technologies in areas that are «poised for this kind of approach,» such as gene transcription and autism studies.

Thus, the late phase of LTP in the CA1 region requires transcription during a critical period, perhaps because cAMP - inducible genes must be expressed during this period.

They tested their system on a pair of yeast transcription factors and used the data to predict which yeast genes the proteins would target, they report in this week's Science.

The researchers also showed that histone propionylation can drive transcription in the test tube (in vitro) suggesting it is a stimulatory mark capable of causing genes to be expressed when it is present.

This work, published in the journal Molecular Cell, reveals a new role for each nucleus» several hundred pores, which constitute as many microscopic factories of gene transcription.

This reflects the normal daily variations of transcription activity in these genes.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

In their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteinIn their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteinin the expression of genes into proteins.

Jones, 62, is an expert in transcription elongation, a process that controls the expression of HIV and cancer genes; she has been at the Salk since 1986.

An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes.

Blau's group found that the daily changes in Rho1 activity are controlled by rhythms in transcription of a gene very similar to human Puratrophin - 1.

Rutgers University scientists have discovered the three - dimensional structure of a gene - specific transcription activation complex, providing the first structural and mechanistic description of the process cells use to turn on, or activate, specific genes in response to changes in cell type, developmental state and environment.

Under his leadership, teams of scientists developed high - throughput assays in the areas of oncology, inflammatory and metabolic diseases, viral transcription, and gene function.

These include proteins which control important processes in the cells, for example the transcription factors which activate genes for the production of new proteins.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

«The paper provides a dazzling snapshot of the process of transcription activation — the process whereby a gene is turned on in response to an instructive signal from the environment,» said Ann Hochschild, professor of microbiology and immunobiology at Harvard Medical School, who also was not part of the study.

In a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicatIn a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicatin the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicate.

Although the majority of genes related to energy production, cell division, and metabolism in M. jannaschii are most similar to those found in Bacteria, most of the genes involved in transcription, translation, and replication in M. jannaschii are more similar to those found in Eukaryotes.

The proteins in turn are the workhorses of biology, spurring chemical reactions inside cells and controlling the expression, transcription, and replication of the genes themselves.