Sentences with phrase «transcriptional regulation of gene»

In this review article, we highlight transcriptional regulation of gene expression in response to drought.»

The SMF's microarray service offers a comprehensive set of integrated gene expression services that facilitate studying the role of genomic alterations and transcriptional regulation of genes.

Not exact matches

The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.

A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.

Furthermore, if transcriptional regulation of adipose tissue function contributes to adiposity - dependent modulation of insulin sensitivity, blood pressure, and other medically important traits, then the genes that correlate with body mass will be candidates for mediating these responses and warrant further evaluation.

Transcriptional regulation information for a gene, including any predicted DNA binding site motifs (YeTFaSCo) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence.

His research interests involve pharmacogenomics for hemoglobinopathies and neuropsychiatric disorders, transcriptional regulation of human fetal globin genes and genotype - phenotype correlation in human genetic disorders.

Major Symposium A: Transcriptional Control of Immunity: Diverse Regulatory Mechanisms in Gene Regulation Chairs: Amy S. Weinmann, Univ. of Alabama, Birmingham Boris Reizis, New York Univ..

BR homeostasis is controlled through transcriptional feedback regulation of these biosynthetic genes by known BR signaling TFs, BRASSINAZOLE RESISTANT1 (BZR1) and BRI1 - EMS - SUPPRESSOR1 (BES1) / BZR2.

But more importantly this old study (by mitochondrial membrande phospholipid fatty acids composition remodeling towards a low perodizable index PI and double bond unsaturation index DBI by genetically reduced desaturase (essentially switching perodizable polyunsaturates with monounsaturates / saturates, rendering membranes lipid peroxidation resistant / blocking hydroperoxide formation by DHA n - 3 and lowering mitochondrial DNA lesions formation by membrane lipid peroxidation chain propagation), It's true though that these effects are due to transcriptional lipid genes regulation (so the genes are the reason of this dramatic effect and this is also a gene therapy, that hit the key points) this old study showed

Research by Sharon Dent and colleagues revealed for the first time that histone modifications - instead of being an end - point for transcriptional regulation - can actually relay information to non-histone proteins, and that the role of chromatin in these events is not limited to DNA - templated events like gene activation.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

Transcriptional Control / Gene Regulation Identification and characterization of injury and regeneration - responsive endocardial enhancer elements Brian Black, University of California, San Francisco Untangling the regulatory pathways controlling vascular differentiation Sarah De Val, Oxford University

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Transcriptional and post-transcriptional regulation of ribulose 1,5 - bisphosphate carboxylase gene expression in light - and dark - grown amaranth cotyledons

The specific transcriptional regulation of tor points to multiple and distinct regulatory mechanisms for different maternal genes, rather than a general mechanism for the regulation of nurse - cell transcription.

We plan to develop new methods and tools for (1) improving the prediction of TFBSs; (2) predicting TF gene targets; (3) prioritizing cis - regulatory variants dysregulating microRNA transcriptional regulation with downstream impact on the gene regulatory programs in cancer.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Xu is developing computational algorithms for the design and analysis of high - throughput biological experiments with a focus on applications in transcriptional and epigenetic gene regulation.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Betsy M. Martinez - Vaz, Irina Makarevitch, Shane Stensland (2010) Studying Gene Expression: Database Searches and Promoter Fusions to Investigate Transcriptional Regulation in Bacteria Journal of microbiology and biology education.

Furthermore, ALI - FRECs were able to support infection and replication of FHV - 1, as well as modulate transcriptional regulation of various immune genes in response to infection.

Determining the transcriptional regulation pattern of PgTIP1 in transgenic Arabidopsis thaliana by constructing gene