Sentences with phrase «transduction at»

Instead, as he reported in the journal Cell, that mechanical transduction at Merkel discs initiates primarily in the Merkel cells.

Not exact matches

at The Scripps Research Institute and the Burnham Institute, and also at the National Institutes of Health, where her studies spanned signal transduction, cell migration, and neuronal development.

«Dr. Smith, I'm soon going to be leaving the biochemistry program here at Purdue with a Ph.D. involving signal transduction, and I am wondering if you might make a recommendation of some contacts at your company whom I could talk with.

«The Cancer Genome Atlas is a really rich and growing database of publicly available data created to help us understand cancer,» said Horvath, who is a program co-leader of the Signal Transduction in Cancer program at the Lurie Cancer Center.

At the end of the project, the transduction efficiency of the newly made retroviral vectors was tested in hematopoietic cells, and here my «old» techniques came in handy.

In 2014, Gu's research team overturned the common assumption that transduction from the mechanical force takes place at the endings of the sensory nerves in Merkel discs.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

OMC also aims at potentiating the existing Conditional Mutagenesis Facility by implementing novel approaches to attain tissue -, stage - and site - specific transgene expression in mouse mutant strains, mainly through lentiviral vector - mediated transduction of blastocysts.

Immunophilins are now known to function at the crossroads of protein folding and trafficking, and signal transduction.

Murat completed his PhD at NCSU focusing on systems biology of growth factor - mediated signal transduction pathways.

Sophie Jarriault did her PhD on the transduction of the Notch signal in mammals in Alain Israël laboratory at the Pasteur Institute, Paris.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.

She did her PhD on the transduction of the Notch signal in mammals in Alain Israël laboratory at the Pasteur Institute, Paris; she realised her postdoc with Iva Greenwald, at Columbia University NYC, on vulva organogenesis in C. elegans.

The following year, Robert Abraham, Ph.D., who would found the Signal Transduction Research program at the Cancer Center, became its director.

Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].

The lentivirus - encoded shRNAs decreased the abundance of ABL1 and ABL2 by 80 % at day 2 after viral transduction, but ABL1 abundance was slightly increased by day 21 after viral transduction (fig.

Because Addgene viruses are provided at a specific titer, you can better plan your transductions and use a range of reasonable MOIs.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Protein - DNA complexes were then immunoprecipitated overnight with polyclonal Oct4 antibody (sc - 9081, Santa Cruz Biotechnology), a mix of monoclonal Oct4 antibodies (BD Transduction Labs, Santa Cruz Biotechnology, Chemicon), or normal serum controls (Pierce) on a rotator at 4 °C.