Berberine improves insulin signal
transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.
Simplet / Fam53b is required for Wnt signal
transduction by regulating β - catenin nuclear localization.
Nearly all his independent research relates to understanding light perception and signal
transduction by the phytochrome superfamily of light absorbing molecules in plants and, more recently, in microbes.
Roberto Villasenor (Zerial, MPG)-- «Regulation of signal
transduction by endosomal EGFR distribution» (2012)
Modulation of MHC Class II Signal
Transduction by CD19.
ATP hydrolysis enhances RNA recognition and antiviral signal
transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).
In 1995, I began graduate studies on signal
transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.
It is expected that the molecular mechanisms underlying the inhibition of interferon signal
transduction by C proteins would then be fully identified.
Not exact matches
SU101 targets the signal
transduction activated
by a messenger called platelet - derived growth factor, which controls the genes involved in tissue formation and wound healing.
By functionally linking the signal
transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
During the early years of my PhD studies, I was very fascinated
by the exciting discoveries in the field of signal
transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.
OMC also aims at potentiating the existing Conditional Mutagenesis Facility
by implementing novel approaches to attain tissue -, stage - and site - specific transgene expression in mouse mutant strains, mainly through lentiviral vector - mediated
transduction of blastocysts.
These cells were immortalized
by retroviral
transduction of the SV40 T antigen and Telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase complex [4], and then termed HMLE (Human Mammary with Large T and TERT).
Growth of osteosarcoma cells was inhibited
by this drug
by targeting of multiple signal
transduction pathways [41].
His academic research focused on gene regulation and signal
transduction mediated
by ion channels and G proteins.
Augmentation of adenovirus 5 vector - mediated gene
transduction under physiological pH conditions
by a chitosan / NaHCO3 solution.
This is a derivative of the TZM - bl cell line, engineered
by lentiviral
transduction to stably express human FcγRIIb on the surface.
This is a derivative of the TZM - bl cell line, engineered
by lentiviral
transduction to stably express human FcγRI on the surface.
This is a derivative of the TZM - bl cell line, engineered
by lentiviral
transduction to stably express human FcγRIIIa on the surface.
In vivo gene delivery and stable
transduction of nondividing cells
by a lentiviral vector.
Functional correction of T cells derived from patients with the Wiskott - Aldrich syndrome (WAS)
by transduction with an oncoretroviral vector encoding the WAS protein.
We then show that an adapted HK functions in plants
by linking it to a transcriptional response through signal - dependent nuclear translocation of a bacterial response regulator [12], to produce a synthetic signal
transduction system.
In addition, because we developed PhoB - VP64 for plants
by activating endogenous HKs with exogenous cytokinins [12], it is likely that our synthetic signal
transduction system (receptor → HK → PhoB: VP64 → signal receptive promoter) has false input or cross-talk from plant HK components.
Approaches successful in other systems, such as modeling signal
transduction and synthetic biology methodologies [32] could improve future generations of detector plants
by enhancing signal transmission and providing means to deal with biological «noise».
Manno, Catherine et al. «Successful
Transduction of Liver in Hemophilia
by AAV - Factor IX and Limitations Posed
by the Host Immune Response.»
Homer 1, an actin binding protein that is induced
by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal
transduction, synaptogenesis and receptor trafficking at synapses [75].
Drugs like Gleevec ®, known as signal
transduction inhibitors, work
by «turning off» specific proteins in cancer cells that cause cancer cells to grow and multiply.
The lentivirus - encoded shRNAs decreased the abundance of ABL1 and ABL2
by 80 % at day 2 after viral
transduction, but ABL1 abundance was slightly increased
by day 21 after viral
transduction (fig.
We have identified three classes of signal
transduction mechanisms that may be mediated or modulated
by NG2.
The novel reprogramming approach employed the retroviral
transduction of Oct4, Sox2, and Klf4 in mouse embryonic and adult fibroblasts followed
by treatment with the GSK3β Inhibitor BIO and the pleiotropic cytokine Oncostatin M (OSM).
Symposia III: Mechanisms of Baro and Chemoreceptor Sensory
Transduction: A Link to Sympatho - excitation in Disease Researchers will discuss how sensory neuronal signals are powerful regulators of the hypertensive state and the role of gaseous messengers in oxygen Sensing
by the carotid body.
In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal
transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked
by a catalytically inactive pseudokinase domain with kinase - regulatory activity,
by an atypical SH2 domain and
by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10
Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated
by a signal
transduction pathway that appears to involve an amino acid sensing GPR [37].
For the OM, enriched genes are dominated
by those encoding ORs and, those involved in the olfactory
transduction pathway and sensory perception.
Introducing new DNA often is achieved
by viral
transduction of target cells with a therapeutic transgene, through either a direct or cell - based gene therapy modality.
Both transient transfection with Lipofectamine and
transduction with adenovirus resulted in a subpopulation of cells that experessed human IgG, as shown
by the increased fluorescence intensity.
In this study we review the most commonly used indel detection methods and using a robust, sensitive, and cost efficient Indel Detection
by Amplicon Analysis method, we have investigated the impact of the most commonly used CRISPR / Cas9 delivery formats, including lentivirus
transduction, plasmid lipofection, and ribo nuclear protein electroporation, on the dynamics of indel profile formation.
Detection of subclonal L1
transductions in colorectal cancer
by long - distance inverse - PCR and Nanopore sequencing
This induced pluripotent stem cell (iPSC) line was generated from IMR90 fetal lung fibroblasts
by viral
transduction of a combination of OCT4, SOX2, NANOG, and LIN28 genes.
Transduction of the lentivirus into the mammary transplants was confirmed
by the expression of ZsGreen.
Sugar - induced cephalic - phase insulin release is mediated
by a T1r2 + T1r3 - independent taste
transduction pathway in mice.
Finally, it must be acknowledged that our data are potentially limited
by providing only a single «snapshot» during recovery and the possibility exists that our muscle biopsy time - points failed to coincide with peak phosphorylation responses of signal
transduction.
The idea of the
transduction of memory into the physical of the body is often observed
by practitioners of body work such as yoga.