Deletion of the TAM from a naive strain of E. coli results in a drastic time delay in folding of UshC, which can be observed for a
protein from EPEC as well as for two introduced
proteins from related organisms, Yersinia and Enterobacter We suggest that this models why the TAM machinery is
essential for efficient folding of
proteins acquired via lateral gene
transfer.
Iron — This nutrient is an
essential component of hemoglobin, an erythrocyte
protein that
transfers oxygen from the lungs to the tissues.