«The paper is a meticulous dissection of all technical steps involved in the procedure of nuclear DNA
transfer for clinical purposes of preventing mitochondrial DNA (mtDNA) disease inheritance.
Not exact matches
Although the probability is very low, the take home message is that
for clinical purposes, we should focus on the
transfer of single spindle or a polar body, which would carry less mitochondria than the standard
transfer of two pronuclei after fertilization.
The
purpose of this study was to investigate the feasibility of in vivo 13C → 1H hyperpolarization
transfer, which has significant potential advantages
for detecting the distribution and metabolism of hyperpolarized 13C probes in a
clinical MRI scanner.
Our improved IVM culture conditions may be used
for obtaining mature oocytes
for clinical purposes and / or
for derivation of embryonic stem cells following parthenogenesis or nuclear
transfer.