Not exact matches
A team of researchers from DuPont added so - called morphogenic genes — known from basic research to promote the production of
embryonic tissue — to the other genes being
transformed (in this case to express green fluorescent protein as a marker of transformation).
When normal cells are
transformed into cancer cells, this epithelial
tissue can take on the characteristics of
embryonic tissue, known as mesenchymal
tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized
tissues.
The new cells, which Yamanaka called induced pluripotent stem (iPS) cells, looked and behaved like
embryonic stem cells, which are prized for their ability to
transform themselves into almost any kind of
tissue and, perhaps, someday cure disease — a more distinct possibility now that President Barack Obama has loosened restrictions on stem cell research.
Unlike
embryonic stem cells, which are developmental blank slates that can generate virtually all types of cells found in adult humans, adult stem cells are thought to possess limited potential to
transform into cells found in their
tissues of origin.
These genes normally guide
embryonic heart development; however, in the adult mice hearts, they helped
transform non-beating cells that form scar
tissue into beating heart muscle cells.