Sentences with phrase «transform fibroblasts»
Using unique drug cocktails, stem cell scientist Sheng Ding, PhD, a senior investigator at the Gladstone Institutes, can transform fibroblasts (skin cells) into fully functional brain, heart, liver, and insulin - producing pancreas cells.
https://gladstone.org/
For example, success rates might be improved by transforming the fibroblasts within living hearts rather than in a dish — something we also observed during our initial experiments in mice.»
Activation of Stat3 in v - Src - transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity
Not exact matches
Homologous recombination was used to introduce a nominally transforming mutation into an endogenous H - ras1 gene in Rat1 fibroblasts.
Mouse fibroblasts transformed with this clone bind serotonin agonists and antagonists and exhibit an increase in intracellular Ca2 + concentrations in response to serotonin.
Earlier laboratory studies had shown that fetal fibroblasts, closely related cells from the fetus, respond to tamoxifen by producing a natural peptide called transforming growth factor beta - 1 (TGF beta - 1).
The most common fusion they observed involved the genes FGFR (fibroblast growth factor receptor) and TACC (transforming acidic coiled - coil).
They have already shown that they can transform human fibroblast cells into pluripotent stem cells, and now plan to start working on delivering the proteins needed to differentiate stem cells into specialized tissues.
Then, by treating the fibroblasts with a unique «cocktail» of molecules and reprogramming factors, they transformed the cells into endoderm - like cells.
«When we injected GMT into each of the three types of human fibroblasts, nothing happened — they never transformed — so we went back to the drawing board to look for additional genes that would help initiate the transformation,» said Gladstone Staff Scientist Ji - dong Fu, PhD, the study's lead author.
The authors identified MELK's transforming activity in HMEC - DD - NeuT cells and demonstrated that MELK can transform Rat1 - DD fibroblasts in a Neu - independent fashion.