Scientists at Columbia's Zuckerman Institute have uncovered new insights into how stem cells
transform into brain cells that control leg movements.
Not exact matches
Crayfish have a «nursery» in their heads where blood
cells transform into neurons — the process may one day help us to regenerate our own
brain cells
The team at the University's Medical Research Council Centre for Regenerative Medicine were surprised to find the molecules can also boost direct conversions from one type of mature
cell to another — including
transforming skin
cells into brain cells.
Scores of laboratories at universities and in private industry are uncovering how to use these
cells, which
transform into neurons, astrocytes (the
cells that regulate transmission of electrical impulses in the
brain) and oligodendrocytes (which insulate nerve fibers with a fatty coating).
Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to
transform cells in the
brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center in Chicago.
The team used human embryonic stem
cells — which can
transform into any
cell of the body — and cultured them in a mixture of chemicals to grow human
brain cells.
Scientists are hopeful that ultimately these
cells could be
transformed in the laboratory to yield specific
cell types needed for a particular treatment, or to cross the «blood -
brain barrier» by expressing specific therapeutic agents that are released directly
into the
brain.
The two groups took skin
cells from patients and
transformed them
into the type of
brain cells that are affected by Alzheimer's.
These rare, damage - repairing
cells are found in many organs (including the
brain), but the
cells can
transform into only a limited range of
cell types.
They then
transformed these
into dopamine - producing
brain cells.
With a bit of persuasion they can be
transformed into pluripotent stem
cells capable of developing
into all manner of tissues, from bone to blood to
brain.
Their findings suggest that even the earliest animals had the makings of both vertebrate and invertebrate visual systems, and that some of the photoreceptor
cells in the invertebrate
brain were
transformed through a series of steps
into vertebrate eyes.
Indeed, recent data demonstrate that when microglial
cells are removed from the
brain and cultured in vitro, they rapidly
transform into something else.
Using unique drug cocktails, stem
cell scientist Sheng Ding, PhD, a senior investigator at the Gladstone Institutes, can
transform fibroblasts (skin
cells)
into fully functional
brain, heart, liver, and insulin - producing pancreas
cells.
SAN FRANCISCO, CA — In a major breakthrough, scientists at the Gladstone Institutes
transformed skin
cells into heart
cells and
brain cells using a combination of chemicals.
In a major breakthrough, Gladstone scientists
transformed skin
cells into heart
cells and
brain cells using a combination of chemicals and without adding external genes to the
cells.
In a major breakthrough, scientists at the Gladstone Institutes
transformed skin
cells into heart
cells and
brain cells using a combination of chemicals.
SAN FRANCISCO, CA — June 7, 2012 — Scientists at the Gladstone Institutes have for the first time
transformed skin
cells — with a single genetic factor —
into cells that develop on their own
into an interconnected, functional network of
brain cells.
In a paper being published online today in the scientific journal
Cell Stem
Cell, Sheng Ding, PhD, reveals efficient and robust methods for
transforming adult skin
cells into neurons that are capable of transmitting
brain signals, marking one of the first documented experiments for
transforming an adult human's skin
cells into functioning
brain cells.
The team managed to
transform astrocytes (a type of supporting
cells in the
brain)
into neurons directly within the
brain of rats.
They include the first phase of our skin for
transforming sunlight
into vitamin D3, building
cell walls throughout our bodies, and comprising most of our
brains» structure.