Sentences with phrase «transgene expression»
"Transgene expression" refers to the process where a gene, which has been transferred from one organism to another, is turned on or activated in the recipient organism. This results in the production of a specific protein or trait determined by that gene. Full definition
Nuclear - associated plasmid, but not cell - associated plasmid, is correlated with transgene expression in cultured mammalian cells.
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for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.
Another type of vector, based on adenovirus, could infect non-dividing cells, but without sustained transgene expression.
Interestingly, a transcriptional analysis revealed that transgene expression from not completely silenced viral vectors could, in fact, perturb global gene expression in hiPSCs [8].
The study investigated the effects suppression of transgene expression by doxycycline (Doxy) feeding on complex behavioral readouts and the correlation to changes in brain pathology.
By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
OMC also aims at potentiating the existing Conditional Mutagenesis Facility by implementing novel approaches to attain tissue -, stage - and site - specific transgene expression in mouse mutant strains, mainly through lentiviral vector - mediated transduction of blastocysts.
Other research showed that channelrhodopsin - 2 (ChR2) activation induced backward swimming in a sparse transgene expression line (Zhu et al., 2009).
The vectors could integrate into the genome, permitting long - term transgene expression, but they could only infect actively dividing cells.
MALDI - MS analysis revealed an absence of Aβ signal in non-transgenic animals (Figure 5) at both time points, indicating that detected Aβ peptides predominantly derive from the human APP transgene expression or reflecting the low level of endogenous rodent Aβ [51].
He also studied the influence of the intraocular environment on viral vector - mediated transgene expression.
Plk4 transgene expression was shut down postnatally in the surviving mice and PLK4OE mice never developed skin tumours.
For this reason, the GEM Facility does not guarantee transgene expression.
We have found that adenoviral transduction results in high levels of transgene expression for at least two weeks.
A significant advantage of ZFN gene modification, compared to retrovirus based approaches, is that only transient transgene expression is required to permanently engineer an HIV resistant cell.
, could infect non-dividing cells, but without sustained transgene expression.
Shutting down transgene expression by Doxy is a useful benchmarking for preclinical treatment trials for drugs addressing tau pathology.
Additional studies are attempting to determine if the transgene expression of various anti-apoptotic genes can protect T cells from tumor - induced apoptosis.
Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression.
Researchers have also developed integrase - deficient lentiviral vectors for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.
Sustained high - level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector - transduced CD34 + cells.
Increases transduction efficiency and transgene expression.
Visualization of vector tissue distribution and transgene expression with morphological context in any animal model