"Transgenic animals" refers to animals that have been genetically modified by scientists. They have genes from other organisms inserted into their DNA to give them new characteristics, such as the ability to produce certain proteins or resist certain diseases.
Full definition
Use
of transgenic animals in the study has been approved by the Biosafety Committee of the Universitat Autònoma de Barcelona.
For example, researchers can now use combinations of
transgenic animal models and modern imaging techniques to view single cells buried deep within embryos.
«Advanced Cell Technology has the ability to produce
transgenic animals using fetal fibroblast nuclear transfer,» claims Steve Parkinson, president and chief executive officer.
BERN — Swiss voters yesterday overwhelmingly rejected a nationwide referendum that would have banned research
on transgenic animals as well as patents on genetically modified organisms.
Thanks to CRISPR gene - editing tools, researchers can tweak the rat genome to create so - called
transgenic animals with human - like disease traits.
Approve of stem cell research,
transgenic animal research and human gene therapy, although strict laws are needed to alleviate concern about ethical issues
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Brian Ager, of the industry's Senior Advisory Group Biotechnology, says the delay will drive business to the US, where patents
for transgenic animals have been granted for some time.
Dolly the sheep was cloned, in fact, with the intention of eventually using this procedure to
create transgenic animals having useful properties, not as a means to make carbon copies of baseball legend Ted Williams or a favorite dead pet.
We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce
other transgenic animal species.
A few years after he arrived in Carbondale to run SIU's physiology department, he began collaborating with Thomas Wagner, a geneticist at Ohio University in Athens who was a pioneer in
engineering transgenic animals.
«Many provisions for the regulation of
conventional transgenic animals may not apply to genome editing,» says Susan Harper from the Agricultural Research Service, part of USDA, in Beltsville, Maryland.
Using a combination of human tissue biopsies,
novel transgenic animal models and cell culture studies, the researchers established a link between expression of MMP3 and activation of Rac1b.
In turn this could lead to the realistic prospect of using SCNT to generate stem cells for therapeutic purposes in humans as well as
generating transgenic animals that are healthy, fertile and productive.
«After three months,» Zhou said, «the running animals showed much better movement and cognitive function compared to
control transgenic animals which had locked running wheels.»
While a post-doctoral fellow at the University of Cincinnati College of Medicine, he succeeded in establishing a variety of
useful transgenic animal models to elucidate mechanisms of cardiac excitation - contraction coupling and heart failure.
We welcome all attendees who are in the process of generating genetically - modified animals or who perform the experiments that follow to determine the corresponding phenotypes of
such transgenic animals.
These findings are supported by another study reporting decreased activity of complex IV in a
triple transgenic animal model (P301Ltau / APP / PS1)[60].
Plato is not reported to have been worried by selective abortion (infanticide was then accepted) or patents
on transgenic animals.
Parkinson contends that targeted gene replacement produces cells having specific genetic alterations far more effectively than the traditional technique for
making transgenic animals, which entails injecting DNA into cell nuclei.
The finding may be important for breeders who want to use cloning to
create transgenic animals, because mitochondria may be home to some crucial genes.
Other transgenic animals, such as glow - in - the - dark pet fish or fast - growing salmon, might prove economically valuable, but Murray's goat «addresses the dysentery pathogen taking up residence in the gut.»
BETHESDA, Md., Mon., Jan. 26, 2004 - A Japanese - U.S. team today reported the successful creation of
transgenic animals using sperm genetically modified and grown in a laboratory dish, an achievement with implications for a wide range of research from developmental biology to gene therapy.
«Conventional techniques of
producing transgenic animals, such as microinjection of genes into eggs and the retroviral transduction of genes into embryos, often produce many animals that are mosaic, which means they do not contain the foreign gene in all their cells.
Taking a new legal tack, Rifkin's group has demanded that the agency should study the impact
of transgenic animals on health and the environment before issuing more patents.
Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of
transgenic animal models that will shed new light on human development and disease.
This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in
the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol.
But
transgenic animals, from mice to pigs, have proven vital to medical research.
The U.S. Food and Drug Administration aims to ensure the safe use of
transgenic animals and approved the first drug from transgenic goat's milk — an anti-clotting protein — earlier this year.
Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in
the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.
To better understand how HMGA1 affected the rodents» intestines, Resar and Lingling Xian, M.D., Ph.D., research associate at the Johns Hopkins University School of Medicine, and their colleagues examined
the transgenic animals» intestinal cells to determine which ones were expressing this gene.
While previous investigations into the protein's effects have used either mice in which gene expression was knocked out or
transgenic animals that expressed human gene variants throughout their lifetimes, the MGH - MIND - led study used a different approach to investigate the effects of introducing the variant forms of the protein into brains in which plaque formation had already begun.
Next they bred
these transgenic animals with mice lacking their own apoE gene, creating animals whose astrocytes made only human apoE.
Prather's pigs won't be going to market anytime soon, however;
no transgenic animal has yet been approved for human consumption in the United States.
To patent
a transgenic animal or plant, however, violates the normal distinction most world views and value systems draw between what is alive and what is not.
Much the same applies to
transgenic animals.
In a relative ranking of potential gains, genetic testing won the most public support, followed by new medicines and vaccines, pest - resistant crops, enhanced food production, and
transgenic animals for biomedical research or cell or organ donation (xenotransplants).