I continue this line of research as such, and I currently am the principal investigator on multiple projects involving
translational studies involving cell or gene therapy -.
Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on
a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.
Not exact matches
«I think it's a very well - done
study,» says Keith Vossel, a
translational neuroscientist at the University of California, San Francisco (UCSF), who was not
involved with the work.
The
study results, published in Science
Translational Medicine, raise questions about the possible transmissibility of prion diseases via medical procedures
involving skin, and whether skin samples might be used to detect prion disease.
The California - Australia collaborative projects are case
studies in how to put together the components of the
translational pipeline, say those
involved.
She ultimately chose to
study leukemia patients» immune responses to bone marrow transplants, an area conducive to
translational research in part because the work
involves treating patients with human cells, which can be prepared at academic health centers.
«This is a very exciting and interesting and, to be honest, important observation in the world of cancer susceptibility,» says Stephen Chanock, the chief of
translational genomics at the National Cancer Institute in Bethesda, Maryland, who was not
involved in the
study.
Oncology investigators in the NC State Center for Comparative Medicine and
Translational Research, for example, focus on understanding the pathogenesis and treatment of cancer through
studies involving, in part, spontaneous models of cancer provided by Terry Center oncology patients.
Clinical
studies in the Center for Comparative
Translational Research
involve patients from the Purdue University Veterinary Teaching Hospital or samples from the Animal Disease Diagnostic Laboratory.