Sentences with phrase «translational studies of»

Its biospecimen repository is still used in translational studies of HTLV biology and pathogenesis by our lab and international collaborators.

The second laboratory continues to focus attention on transplantation immunobiology in mouse models and translational studies of human immunology in transplant recipients.

Not exact matches

Eric Topol is a cardiologist who studies aging and the director of Scripps Translational Science Institute.

A 2013 Clinical and Translational Immunology study found that when a baby is ill, the numbers of leukocytes in its mother's breast milk spike.)

«Nonetheless, the proof of concept studies we have obtained thus far are extremely encouraging, and we are confident that with proper support and efforts we could translate our findings into experimental therapeutics for a variety of solid tumors that are driven by EphA2 overexpression, including breast, lung, prostate, pancreatic, and ovarian cancers,» said Pellecchia, who serves as the founding director of the Center for Molecular and Translational Medicine at UCR.

A study in the journal Science Translational Medicine details a new procedure for making damaged, donated lungs functional, potentially doubling the number of lungs available for transplant.

«But that's really not what the study tested,» says Manji, whose commentary on the study was published in the same issue of Science Translational Medicine.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

The lead author of the study was Jacqueline French, MD, professor of neurology and director of Translational Research & Clinical Trials Epilepsy at NYU Langone's Comprehensive Epilepsy Center.

Lee Gehrke, the Hermann L.F. von Helmholtz Professor in MIT's Institute for Medical Engineering and Science (IMES), is also a senior author of the study, which appears in the Sept. 27 issue of Science Translational Medicine.

Lance Price at the Translational Genomics Research Institute in Flagstaff, Arizona, and colleagues studied the microbes from the penises of 12 HIV - negative men.

Further dose escalation and dose expansion studies are underway as well as translational tissue - based experiments to clarify the impact of this treatment combination.»

«To treat most forms of hearing loss, we need to find a delivery mechanism that works for all types of hair cells,» said neurobiologist David Corey, co-senior investigator on the study and the Bertarelli Professor of Translational Medical Science at HMS.

In a study published online June 21 in the Annals of Clinical and Translational Neurology, the researchers show that the consumption of extra-virgin olive oil protects memory and learning ability and reduces the formation of amyloid - beta plaques and neurofibrillary tangles in the brain — classic markers of Alzheimer's disease.

Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a proof - of - concept study led by the National Cancer Institute (NCI) and the Translational Genomics Research Institute (TGen).

«This is a missing piece in the puzzle of the pathogenesis of dengue,» said Harris, senior author of the study to be published in the journal Science Translational Medicine.

An example of such translational engagement is the NOAA - funded Climate Impacts Group at the University of Washington, Seattle, which studies the impacts of climate change on water, fishery, coastal, and forest resources in the Pacific Northwest.

A resurgence in whooping cough cases in the U.S. is likely due to incomplete vaccine coverage in the past combined with waning protection from the vaccine, according to a new study published in the March 28 issue of Science Translational Medicine.

«I think it's a very well - done study,» says Keith Vossel, a translational neuroscientist at the University of California, San Francisco (UCSF), who was not involved with the work.

«Understanding the mechanism of action of this peptide will help in translational studies to further assess the potential for this peptide to be used in medicine,» Beales says.

I'm delighted at the prospect of a new treatment that's a lot more potent, all the more because it lowers LDL at the same time,» said study co-author Richard L. Dunbar, MD, assistant professor of Cardiovascular Medicine and member of Penn's Division of Translational Medicine and Human Genetics.

That friend introduced him to Dietrich Stephan, now the chief science officer of Navigenics, who had been studying the genetics of disorders such as autism and exercise - induced heart attacks at the Translational Genomics Research Institute in Arizona.

Babies who develop food allergies display hyperactive immune responses at birth, according to a study of about 1000 infants published in the 13 January issue of Science Translational Medicine.

The study results, published in Science Translational Medicine, raise questions about the possible transmissibility of prion diseases via medical procedures involving skin, and whether skin samples might be used to detect prion disease.

Bruce Littman, president of Translational Medicine Associates, LLC, in Stonington, Connecticut, moved to an industry position at Pfizer after studying the pathogenesis of rheumatoid arthritis as a professor at Virginia Commonwealth University in Richmond.

Importantly, these cells are readily detectable in patients» bloodstream, allowing for any clinical tests to be minimally invasive and pain - free for patients,» said Professor Salvatore Albani, Director, SingHealth Translational Immunology and Inflammation Centre (STIIC), Professor, Duke - NUS Medical School and Senior Clinician Scientist, KK Women's and Children's Hospital (KKH), who is the principal investigator of the study.

The results of the study appear in the latest edition of the scientific journal Translational Psychiatry.

«There are clearly molecular differences between African - American and Caucasian multiple myeloma cases, and it will be critical to pursue these observations to better improve clinical management of the disease for all patients,» said John D. Carpten, senior author of the study and chair of the Department of Translational Genomics at the Keck School of Medicine.

Rebecca Jackson, the study's senior author and director of Ohio State's Center for Clinical and Translational Science, said the new findings support a growing body of evidence that factors that increase inflammation can increase osteoporosis risk.

Other researchers include Randy Strong, Department of Pharmacology and Barshop Institute for Longevity and Aging Studies, UTHSC, San Antonio, TX; Clifford Rosen, Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME; and Michael Nelson, Heart Institute, Cedars - Sinai Medical Center, Los Angeles, CA.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

The latest study of a new at - home test kit, published today in Science Translational Medicine, found that even untrained users were able to measure sperm count and concentration as well as motility (the percentage of actively moving sperm), detecting abnormal semen with 97 percent accuracy compared with traditional lab testing.

The study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23 HD054720), Flora Family Foundation, UCSF Catalyst Award, UCSF Resource Allocation Program, Brain & Behavior Research Foundation Young Investigator Award, Stanford University Lucile Packard Foundation for Children's Health, Spectrum Child Health & Clinical and Translational Science Award and the Extraordinary Brain Series of the Dyslexia Foundation.

«The study focuses our attention on a particular part of the immune system that already exhibits changes caused by Alzheimer risk factors in people in their 20s and 30s,» said Philip L. De Jager, MD, PhD, director, BWH Program in Translational NeuroPsychiatric Genomics, associate member at the Broad Institute, senior study author.

Dennis Miller, associate professor in the Department of Psychological Sciences in the College of Arts & Science and an investigator with the Bond Life Sciences Center, and researchers in the Center for Translational Neuroscience at MU, study therapies for drug addiction and neurodegenerative disorders.

Two drugs recently showed promise in clinical trials, and now a study in Science Translational Medicine offers both an unprecedentedly deep explanation of how the disease progresses and introduces another potential therapeutic avenue.

The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»

The study was supported in part by the National Institutes of Health (DA024806, R01DA032889 - 01A1, DA018197 - 05); the Tufts Medical Center's Natalie Zucker and Susan Saltonstall grant; the Joel Alpert Foundation Grant; MD Anderson's Cancer Center Support Grant (DA026120); the National Center for Advancing Translational Sciences (UL1 TR000073); and the Toomin Family Fund.

The California - Australia collaborative projects are case studies in how to put together the components of the translational pipeline, say those involved.

«We are excited that our translational research team of clinicians and basic researchers have come together to present these novel findings and hope that future studies and trials based on this work can move forward to bring targeted therapies for TED,» commented Dr. Phipps.

With the technology on track for commercialization, Rogers» team, including Dr. Roozbeh Ghaffari, the director of translational science at CBIE, is continuing to test the microfluidic devices in scaled studies with an expanding collection of partners.

Reporting the results of a second study from the same group, Dr Suzanne Drury, a translational research and development scientist from Great Ormond Street Hospital, will describe the team's experience in the use of NIPD (non-invasive prenatal diagnosis) to diagnose the disorder congenital adrenal hyperplasia (CAH).

In a small study, supported by Ohio State's Center for Clinical and Translational Science (CCTS) Davis Bremer Pilot Award, Powers identified more than 140 micro-RNAs that are present in the spinal fluid of eight patients who had an SAH followed by DCI.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

Early findings from a human trial of the process and from animal studies were published today in Science Translational Medicine.

«This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition,» says Eloise Hudry, PhD, of MGH - MIND, lead author of the Science Translational Medicine report.

The method, published in the 1 March issue of Science Translational Medicine, could help make organ banks a viable option for transplant surgeons, said John Bischof of the University of Minnesota, the senior author on the study.

The study, which was published in the last issue of Science Translational Medicine, reports early plasma cytokine signatures that correlate with, and predict, the immunogenicity and reactogenicity of the vaccine.

The finding warrants research into adding drugs that could prevent the cancer from hijacking patients» repressive gene regulatory machinery, which might allow the original therapy to work long enough to eradicate the tumor, the researchers report in their National Institutes of Health - funded study, published in the current issue of Science Translational Medicine.

«Our brains require a tremendous amount of energy and in order to meet this demand the flow of blood must be precisely choreographed to ensure that oxygen is being delivered where it is needed and when it is needed,» said Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study.