«In normal itching, there's a fixed pathway that
transmits the itch signal,» said senior investigator Zhou - Feng Chen, PhD, who directs Washington University's Center for the Study of Itch.
That's because chronic itching appears to incorporate more than just the nerve cells, or neurons, that normally
transmit itch signals.
The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells
transmit itch signals from the skin to other cells in the spinal cord.
Not exact matches
The mice also scratched if they lacked the calcium channel that
transmits chloroquine - induced
itch signals and were exposed to chloroquine.
«We found that the TRPV1 channel that processes histamine - induced
itch seems to work as a kind of molecular chaperone in the sensory neurons, helping the other channels process
itch signals and
transmit them to the spinal cord.»
The researchers looked at on how neurons in the dorsal root ganglion process and
transmit two types of
itch signals.
And they also learned that TRPV1, the channel that
transmits histamine - induced
itch, also plays a role in chloroquine - induced
itch by helping TRPV4 process
itch signals.