Not exact matches
Two men known only as the «Boston patients» have both stopped taking their anti-HIV medications following
transplants of bone - marrow stem
cells that
appear to have banished the virus from their bodies.
In people with severe eye disease,
transplants made from embryonic stem
cells (in region of black dotted circle)
appear safe, and became larger and more pigmented over time (right).
In this study, Cherqui's team
transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they
appeared to transfer wildtype FXN into deficient neurons and muscle
cells.
Scholl is upbeat that the
transplanted cells still
appear safe and says that analysis of the
cells in the recipients» eyes are «indeed an indication that something is happening.»
«It thus
appears quite possible that these selective agonists will be administered in the future to patients who are candidates for allogeneic stem
cell transplants.
It
appears that a lack of adequate growth factors plays an important role in the survival of
transplanted cells.
The cornea and its stromal stem
cells themselves
appear to be «immune privileged,» meaning they don't trigger a significant immune response even when
transplanted across species, as in the Pitt experiments.