Marbán, like many, believes the improvements came about because
transplanted cells secreted chemicals that boosted heart function — not because any new heart tissue grew.
Rather, the group speculates that
the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).
Not exact matches
When these
cells were
transplanted into diabetic mice, the
cells secreted insulin and reduced the blood sugar levels of the mice to normal or near - normal levels.
«Our major CIRM - funded programs, aimed at engineering young stem
cell - derived astrocytes to
secrete GDNF, then
transplanting those
cells back into patients, take on even greater importance, given this aging phenomenon,» said Svendsen, the Kerry and Simone Vickar Family Foundation Distinguished Chair in Regenerative Medicine.
The authors
transplanted human cortical ‐ derived neural progenitor
cells engineered to
secrete glial
cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the
cells migrated, matured into astrocytes, and released GDNF.
Human stem
cells successfully used to generate functional pituitary tissue capable of
secreting hormones when
transplanted into rats with hypopituitarism