Scholl is upbeat that
the transplanted cells still appear safe and says that analysis of the cells in the recipients» eyes are «indeed an indication that something is happening.»
Not exact matches
The friction of the shaker afforded him better results, but there were
still too many cadaver
cells to risk
transplant.
The authors write that PBSCs are
still used, despite disadvantages in patients with bone marrow failure, most likely because centers obtain PBSCs routinely for other indications and
cell separators are available at any
transplant center.
In the case of whole pancreas transplantation, major surgery is required; and in beta
cell islet transplantation, the body's immune system can
still attack the
transplanted cells and kill off a large proportion of them (80 % in some cases).
For the other adult patients that might
still benefit from a cord blood donor, either two cord blood units are combined for a single
transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor
cells in the laboratory before infusion or modify the
cells in some way to make them more potent at the time of
transplant.
In contrast, the same
cells transplanted to immunocompromised mice remained highly immunogenic; eight of ten are
still eliminated when
transplanted to wild - type mice (regressor clones).
\ n \ n «It?s
still not clear how the
cells sense shear stress, and researchers are trying to unravel the chain of events between mechanical force and stem
cell production in order to manipulate the process to make blood stem
cells for
transplant.»
Persistent survival of the
transplant was not required in order to obtain benefit after transplantation, as behavioral recovery was as extensive in animals in which
transplanted cells were
still present at 5 weeks as in those in which no human
cells were detected at this time point.
Still, it opens the door towards the prospect of reprogramming brain
cells without the need for any
transplants or surgeries».