Sentences with phrase «transplanting photoreceptor cells»

A team of UK stem cell scientists, led by Dr. Robin Ali from UCL Institute of Ophthalmology in London, has developed a new strategy for repairing the retina by transplanting photoreceptor cells generated in the laboratory from embryonic stem cells.

Some groups, including Lanza's, are looking to do just that: transplant photoreceptor cells.

Not exact matches

Nevertheless, the outcome may pave the way for transplants of stem cell — derived eye cells called photoreceptors, which could dramatically improve vision in people with eye disease if all goes according to plan.

He suspects that transplanted cells are actually restoring the function of «dormant» photoreceptors.

These findings have suggested the development stages at which to transplant cells — for instance, photoreceptor cells need to be relatively more mature than stem cells, according to Thomas Reh, who studies retinal development at the University of Washington.

There are even efforts underway to transplant cultured photoreceptor cells into the retina to replace those lost from advanced disease.

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].

Researchers from the Buck Institute report one of the first demonstrations of long - term vision restoration in blind mice by transplanting photoreceptors derived from human stem cells and blocking the immune response that causes transplanted cells to be rejected by the recipient.

The team transplanted stem cell - derived photoreceptors into another strain of mouse, called CRX null, which is congenitally blind.

Confocal images of P150 dystrophic retina transplanted with hNPCctx — GDNF and double stained with antibodies against human nuclear antigen (red) and either (A) recoverin, a photoreceptor and cone bipolar cell marker (green), or (B) protein kinase Cα (PKCα), a bipolar cell marker (green).

Of note, while vision rescue requires preservation of some functional photoreceptors, the mere presence of photoreceptor cells in the ONL of transplanted RCS rats does not assure function [61].

Qualitative examination of the host anatomical response to the presence of hNPCctx or hNPCctx - GDNF revealed substantial preservation of the photoreceptor outer nuclear layer (ONL) overlying all subretinal donor cells (Figure 5E and F), with photoreceptor rescue gradually declining outside the distribution of the transplanted cells (Figure 5E and G).

The location of transplanted human cells, their expression profile and ability to phagocytose rod photoreceptor material was examined in vivo using immunohistochemistry.

Inset shows higher resolution confocal images of photoreceptor cell nuclear layers (DAPI blue) and rhodopsin expression (red) in the dystrophic control (left inset) and dystrophic with iPS - RPE transplant (right inset) RCS rat.