Sentences with phrase «transplants in human patients»

Rapamycin is a drug currently approved for immunosuppression during preparatory and maintenance regimens for organ and bone marrow transplant in human patients.

Not exact matches

The finding, reported in next month's issue of Nature Medicine, raises new questions about whether people could contract exotic diseases if animal organs become routinely transplanted into human patients.

The second cohort of 140 patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double - blind arm of the study in the next six months.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

In 1988, Freed and his colleague Robert Breeze, MD, performed the first transplant of human fetal dopamine cells into a Parkinson's patient in the United StateIn 1988, Freed and his colleague Robert Breeze, MD, performed the first transplant of human fetal dopamine cells into a Parkinson's patient in the United Statein the United States.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Dr. Blaser is identifying the factors that promote successful engraftment of transplanted cells in animal models, which he will then attempt to translate into improved approaches for human patients.

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

If successful, this may lead to therapies for humans in which a patient's stem cells will be reverted into iPSCs, then genetically repaired and transplanted back into the bone marrow of the same patient.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

Cyclosporine is a modulator of the immune response that has been helpful in both human and non-human organ transplant patients.