The researchers set up a system to grow asymmetric nerve cells in an observation chamber and use live cell imaging to track how rabies virus particles are
transported along the axons.
However, when the researchers grew nerve cells that had no p75NTR in their observation chamber, they found that virus
transport along the axon is less frequent and much slower.
Not exact matches
This interrupts the
transport of cellular materials
along axonal microtubules, causing these materials to accumulate at several points
along the
axon where they may give rise to varicosities.
When the researchers administered drugs to inhibit the movement of certain «motor» proteins that
transport mitochondria and other cargo within the cell by traveling
along microtubules, the mitochondria accumulated in the
axon of the neuron and never made it to the synaptic terminal.
Studies conducted by Hendry at the Australian National University and by K. Stockel and H. Thoenen at the Basel Institute for Immunology have demonstrated that NGF is taken up at the terminal nerve endings of the sympathetic fibers and
transported back to the neuronal cell body
along the
axon.