A cellular protein called PAK1 stimulates the growth of dendritic spines, or protrusions, that allow communication between neurons, and Roy had a hunch that this protein — when
transported into brain cells — might help bring silent engrams back into direct awareness.
Not exact matches
As Pardridge studied the protein more carefully, he realized that it
transports essential insulin
into the
cell and then out the other side, from which point the hormone travels
into the
brain to help regulate eating behavior.
The
brain is protected by a barrier of
cells that tightly regulates the
transport of substances
into this organ in order to prevent infection.
«Until now, it was not possible to look at how neurotransmitters are
transported into cells across large regions of the
brain,» says Aviad Hai, a postdoc in the Department of Biological Engineering and first author of a paper describing the technique in today's issue of Neuron.
One of the genes involved in feeding the big
brain, called SLC2A1, builds a protein for
transporting glucose from blood vessels
into cells.
The endothelial
cells have a receptor for transferrin that acts like a gatekeeper: When transferrin binds to a receptor on the blood side of the barrier, the endothelial
cell transports it (and its iron cargo) to the other side and spits it out
into the
brain.
Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial
cells into transporting the antibody across the blood -
brain barrier.
Researchers at University of Florida Health have discovered the mechanics of how dopamine
transports into and out of
brain cells, a finding that could someday lead to more effective treatment of drug addictions and neurological disorders such as Parkinson's disease.
One theory suggests that because chromium helps
cells be more sensitive to insulin, it also allows insulin to
transport tryptophan — the precursor to serotonin — across the blood -
brain barrier and
into the central nervous system.
In addition, a functional BBB is manifested by a number of permanently active
transport mechanisms, specifically expressed by
brain capillary endothelial
cells that ensure the
transport of nutrients
into the CNS and exclusion of blood - borne molecules that could be detrimental to the milieu required for neural transmission.