Sentences with phrase «treat bone marrow»

There are many therapies and approaches doctors use to treat bone marrow failure disease patients.

After that, Wartman began taking the drug ruxolitinib, which is on the market to treat a bone marrow disorder that leads to anemia.

Not exact matches

Such embryo research might teach us more about cell differentiation and early embryo development, it might make possible greater success in bone marrow transplants, and it might help us to treat more successfully degenerative diseases and spinal cord injuries.

At the age of 19, I was diagnosed with leukemia and treated with chemo and a bone marrow transplant from my sister.

And then came the bone - marrow transplant, a procedure that removes and treats a portion of the diseased marrow, then kills the remaining marrow with massive doses of chemotherapy as much as 10 times stronger than normal.

The 25 - year - old has paid for specialist medical equipment that will be used to treat children suffering from bone marrow cancer.

«Research suggests new way to treat inflammatory gut disease and prevent rejection of bone marrow transplants.»

Luznik and his team inventoried types of immune cells present in the blood of bone marrow transplant patients treated with post-transplant cyclophosphamide.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

The findings, published online Nov. 13 in Science Translational Medicine, could pave the way for improvements in preventing GVHD and rejection of transplanted bone marrow and new therapies to prevent or treat a relapse of the underlying cancer after a transplant.

Bone marrow transplants are sometimes needed to treat immune diseases that attack these stem cells, or in certain types of anaemia, in which the body can't make enough blood cells or clotting factors.

Johns Hopkins Kimmel Cancer Center scientists first used cyclophosphamide to prevent severe graft - versus - host disease (GVHD) after bone marrow transplant involving haploidentical or «half - matched» transplants, a treatment first used in 2000 at the Cancer Center to treat leukemias and other blood cancers.

Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

Researchers at Washington University School of Medicine in St. Louis have developed a nanotherapy that is effective in treating mice with multiple myeloma, a cancer of bone marrow immune cells.

«Bone marrow concentrate improves joint transplants: Study shows treating cartilage grafts before biologic joint replacement speeds healing.»

Researchers at the University of Missouri School of Medicine found in a group of patients that treating donor grafts with bone marrow aspirate concentrate (BMC) before surgery improves bone integration and speeds recovery.

Because there was only one other published case report about a child with M. velutinosus — a 1 - year - old with brain cancer who had undergone a bone marrow transplant — Kumar notes that he and colleagues were at a loss as to how best to treat their patient.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

And in 2010, a 46 - year - old woman developed multiple tumours in her kidney after having her own bone marrow stem cells injected at a private clinic in an attempt to treat her kidney failure.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

One single stem cell from the bone marrow is not going to be able to treat disorders as different as Alzheimer's disease and rheumatoid arthritis,» he says.

The stem cells used to treat Paizley, specific to the blood, came from the bone marrow of a healthy adult donor.

BMT was effective in mice, but in humans resulted in death before the new bone marrow grew and expanded (called engraftment) in treated patients.

Beyond organ transplants, many experts think that the protocol could be used to treat other diseases that require bone marrow transplants but for which there are severe shortages of matched donors.

AML can be difficult to treat and requires intensive chemotherapy and often bone marrow transplantation.

A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.

Because bone marrow, colon, and liver are significantly different tissues, the investigators believe the pathway by which SW033291 speeds tissue regeneration is likely to work as well for treating diseases of many other tissues of the body.

In animal models treated with the compound, fat formation in the bone marrow was successfully blocked independent of their metabolic state (healthy or diabetic).

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

Adult stem cell treatments have been used for many years to treat successfully leukemia and related bone / blood cancers through bone marrow transplants.

The authors say this is most likely to be due to the longer length of hospital stay for blood cancers (14 days on average, compared to 8 days across all cancers), and because blood cancers are increasingly treated with complex, long - term treatments including bone marrow transplants, multi-agent chemotherapy and radiotherapy, and extensive diagnostic procedures.

To treat hereditary blood diseases, doctors could take a sample of bone marrow cells from a patient, correct the faulty gene, and then grow healthy cells in the bioreactor and transplant them back into the patient.

Doctors generally treat aplastic anemia effectively using immunosuppressives — drugs that prevent the immune system from attacking bone marrow — allowing recovery of the patient's own marrow and long - term survival.

Wu wants to build a bioreactor which mimics bone marrow and produces limitless supplies of blood cells that can treat these deficiencies.

«One of the major limitations we see in treating blood cancers is the failure to clear cancer cells from the bone marrow,» said Flavia Pernasetti, PhD, of Pfizer Oncology Research and Development.

Now researchers have successfully treated this pathological behavior in the mice — with a bone marrow transplant.

However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

Cincinnati Children's researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS)-- a group of pre-malignant disorders in which bone marrow does not produce enough healthy blood cells.

In Germany, for example, the Munich - based biotech company apceth has already treated patients» gastrointestinal cancer with stem cells harvested from their own bone marrow and modified to convert a prodrug called ganciclovir.

«Many critically ill cancer and bone marrow transplant patients are treated with Amphotericin B - based therapies each year,» said Abraham Brass of the University of Massachusetts Medical School (UMMS).

Then they injected the treated stem cells, which were assumed to have incorporated the new gene into their DNA, back into the babies» bone marrow.

Antibacterial drugs are sometimes prescribed to treat and prevent infection caused by bone marrow suppression, a side effect of cancer drugs.

More than 30 patients have been treated for SCID, and more than 90 percent of those children have been cured of their disorder — an improvement over the 50 percent chance of recovery offered by bone marrow transplants.

Mice injected with the blocker - treated leukemia cells, however, only exhibited cancer in 2 % of their bone marrow cells.

«Transplantation allows clinicians to treat the cancer most effectively by using more intense doses of chemotherapy than can typically be given, while avoiding fears of wiping out the bone marrow.

It is composed of two elements: treating the patient with antibodies on the day of transplant, followed by a donor bone marrow infusion several days later.

This makes bone marrow transplants, which treat diseases like leukemia and lymphoma, easier, quicker and less painful for the organ donor, lessening the hurdles to donate.

Given the ongoing adoptive therapy trial of CD4 + T cells treated with R5 - ZFNs and the anti-viral success of the recent ccr5Δ32 bone marrow transplant in an HIV - infected patient [6], we sought to determine if cxcr4 could be genetically disrupted simultaneously with ccr5.

In these therapies, the patient's own blood - producing bone marrow cells are treated with radiation and chemotherapy, and the blood of a twin or closely matched donor is instilled.

The patient was treated on an acute lymphoblastic leukemia (ALL) protocol for eight cycles of hyperCVAD (cyclophosphamide, vincristine, adriamycin and decadron) alternating with MTX / Ara - C (methotrexate and cytarabine) and achieved complete remission (CR) confirmed by a bone marrow biopsy and by the resolution of most of her skin lesions.