Sentences with phrase «treat tumors in mice»

The MIT team is now testing this approach to treat tumors in mice and is also working on ways to deliver the antibodies to specific types of cells.

Not exact matches

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrateIn addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstratein which the anti-cancer properties of capsaicin were solidly demonstrated.

Residual tumors, spawned from the remaining cancer cells, were 3.5 times smaller in the treated mice than in untreated mice.

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

In the upper panel, tumor cells formed colonization at day 14, while in the lower panel, when the mouse was treated with the compound edelfosine, most of the tumor cells disappeared at day 10 and failed to form colonization at day 1In the upper panel, tumor cells formed colonization at day 14, while in the lower panel, when the mouse was treated with the compound edelfosine, most of the tumor cells disappeared at day 10 and failed to form colonization at day 1in the lower panel, when the mouse was treated with the compound edelfosine, most of the tumor cells disappeared at day 10 and failed to form colonization at day 14.

After five weeks, the combination treatment in the six mice decreased tumor size by up to 66 percent, compared with six mice treated with only paclitaxel.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Moreover, this approach was effective in treating mice with malignant colorectal cancer tumors containing Kras and p53 mutations, which are found in about half of colorectal tumors in humans.

Then the tumors in most of the treated mice again melted away.

The tumors in Sand's lab might be explained by the high dose, the fact that the mice were newborns, and the type of mouse, suggests Kay, who was involved with a past clinical trial administering AAV to the liver to treat hemophilia.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

And in 2001, molecular biologist Mark Sands at Washington University in St. Louis, Missouri, found a high rate of liver tumors in middle - aged mice that had been treated as newborns with a supposedly safer viral vector.

Treated mice formed fewer tumors and showed less angiogenesis, and half survived to day 40, whereas all untreated mice died within 30 days, the group reports in Science.

We created a mouse xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant tumors were treated with PAL three times a week for 6 weeks.

In a report about their study published online Oct. 17 in Clinical Cancer Research, the researchers described minimal or zero tumor progression in mice treated with the microencapsulated 3BrPIn a report about their study published online Oct. 17 in Clinical Cancer Research, the researchers described minimal or zero tumor progression in mice treated with the microencapsulated 3BrPin Clinical Cancer Research, the researchers described minimal or zero tumor progression in mice treated with the microencapsulated 3BrPin mice treated with the microencapsulated 3BrPA.

By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used chemotherapy drug gemcitabine.

They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

Pentachlorophenol — a substance used to treat utility poles, wood pilings and fence posts — caused tumors in the liver and other organs of mice.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micIn their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micin women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

To find out whether the virus could help treat cancer in a living animal, the researchers injected either Zika virus or saltwater (a placebo) directly into the brain tumors of 18 and 15 mice, respectively.

These types of engineered tumors are much more difficult to treat than human tumors implanted in mice, because they suppress the immune response against them.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

In the treated mice, the treatment strongly reduced the tumor growth with no toxicity to the mice, reports the study in OncotargeIn the treated mice, the treatment strongly reduced the tumor growth with no toxicity to the mice, reports the study in Oncotargein Oncotarget.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

In the replicating lab, however, tumors grew extremely slowly in both treated mice and in controls — and in a few cases spontaneously regresseIn the replicating lab, however, tumors grew extremely slowly in both treated mice and in controls — and in a few cases spontaneously regressein both treated mice and in controls — and in a few cases spontaneously regressein controls — and in a few cases spontaneously regressein a few cases spontaneously regressed.

Yasuaki Tamura, working with colleagues in the laboratory of Pramod Srivastava, demonstrates that tumor - derived heat shock protein - peptide vaccines can be used to treat a wide array of pre-existing tumors in mice.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsIn a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutationsin cases where genetic sequencing of the tumor showed no actionable mutations.3

Tumor sizes decreased in the treated mice, areas of cell death were visible, and all AAV2 treated mice survived through the study, a direct contrast to the untreated mice.

Tumor cells in the placebo - treated mice grew rapidly, to about 200 percent their original size in seven weeks.

By day 60, the average tumor volume in mice treated with tamoxifen plus CDB4124 was 70 percent lower than the original tumors.

Similarly, Cbl - b − / − mice and T cells lacking Cbl - b demonstrate improved control of s.c. - implanted tumors (23) and disseminated leukemia (32), along with decreased spontaneous tumor formation in ATM − / − mice (23) and UV B - treated mice (24).

The tumors formed in mice co-treated with chidamide and decitabine were significantly smaller than those that formed in untreated animals or those treated with the single agents, starting from 15 days of treatment (Figure 4C, left panel), as visualized by 18F - fluorodeoxyglucose small - animal positron emission tomography — computed tomography at 21 days of treatment (Figure 4C, right panel).

In contrast, mice treated with antibody - expressing NSCs showed anti-HER2 IgG at the tumor site, but no human IgG was detectable in the blood (data not shownIn contrast, mice treated with antibody - expressing NSCs showed anti-HER2 IgG at the tumor site, but no human IgG was detectable in the blood (data not shownin the blood (data not shown).

Our ability to detect anti-HER2 antibody at the tumor site but not in the blood of NSC - treated mice suggests that this approach could have robust localized anti-tumor effect, while minimizing the systemic toxicity associated with traditional trastuzumab therapy.

The fourth panel of the upper row shows tumor with no red NSCs in mice treated with trastuzumab alone (sporadic small red dots not associated with cells are visible as autofluorescence background).

In contrast, no PCR product was detected in tumors from mice treated with trastuzumab alonIn contrast, no PCR product was detected in tumors from mice treated with trastuzumab alonin tumors from mice treated with trastuzumab alone.

To study the impact of MELK knockdown on tumor growth, mice were randomly sorted into groups on the second day of injection, and were untreated or treated with doxycycline (2 mg / ml in 5 % dextrose in drinking water, refreshed twice a week) for the duration of the study.

These breast cancer mice were then treated with Bioidentical Hormones (estradiol, progesterone, testosterone) showing a dramatic reduction in tumor size, with better results compared to conventional aromatase treatment.

While tumor growth was reduced in both sets of mice, the tumors of the mice treated with both progesterone and Tamoxifen experienced the greatest growth reduction.

Additionally, tumor weights in the sulforaphane - treated mice were one - fourth those of the control tumors (P < 0.05).