Sentences with phrase «treated human islets»
The blood sugar of the diabetic mice were made normal by the gene - therapy - treated human islets on the right.
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In these two microscopy images, human islets (the source of insulin cells) were poisoned with a drug to remove the insulin cells, and then treated with either an empty virus (left panel) or the therapeutic virus (right panel), and then grown in a diabetic mouse.
The load of IAPP aggregates in islets treated with old Tg - hIAPP islet homogenate was significantly greater than that of the control groups, including untreated human islets and those exposed to the same concentration of WT islet extracts lacking IAPP aggregates (Fig. 2 D).
(C) Human islets, isolated postmortem from nondiabetic individuals, were treated with 1 % islet homogenate from old Tg - hIAPP mice, WT control islet homogenates, or old Tg - hIAPP immunodepleted using a cocktail of sequence and conformational antibodies.
Similar results were obtained when human islets were treated with synthetic IAPP aggregates (Fig. 2, C and D).
Maturation of human embryonic stem cell - derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.