Sentences with phrase «treated older mice»

Because mice, like humans, lose bone as they age, the scientists also treated older mice with LLP2A - Ale.

The researchers also treated old mice with 8 injections of blood plasma taken from either young mice or other geezers.

Not exact matches

Normal mice reach sexual maturity at about 30 days old, but the leptin - treated mice blossomed about 3 days earlier, Flier says.

After 18 - month - old mice were treated with NMN for two months, their capillary density was restored to levels typically seen in young mice, and they experienced a 56 to 80 percent improvement in endurance.

Reyes lab began by treating old dystrophic mice with direct injection of THI.

Researchers found that FTIs not only prevented cardiovascular damage in young mice, but also reversed the disease in older animals treated after the onset of arterial damage.

Importantly, levels of total tau and tau tangles in the brains of treated 12 - month - old mice were lower than in untreated 9 - month - old mice, suggesting that the treatment not only had stopped but reversed the buildup of tau.

By the time the mice were 3 weeks old, the researchers found that their intestines were indeed as leaky as those of mice that had been treated with a chemical that induces colitis.

Now, a new study in mice shows that we may be able to modify DNA to help us treat painful memories no matter how old they are.

Islets isolated from 3 wk - old Tg - hIAPP mice were treated with different concentrations of synthetic IAPP - aggregated seeds for 10 d.

(A) Isolated islets from 3 - wk - old, female, Tg - hIAPP mice were cultured in presence of different concentrations of IAPP aggregates prepared in vitro from synthetic IAPP, as well as controls treated with other amyloidogenic proteins, including the Alzheimer's disease — associated protein Tau (the K18 fragment) and the bacterial amyloid Mcc.

6 — 8 - wk - old BALB / c mice were treated with 200 µg (10 mg / kg of body weight) EM - 4C04, 70 - 1F02, or 1009 - 3B06 human mAb intraperitoneally.

(C) Human islets, isolated postmortem from nondiabetic individuals, were treated with 1 % islet homogenate from old Tg - hIAPP mice, WT control islet homogenates, or old Tg - hIAPP immunodepleted using a cocktail of sequence and conformational antibodies.

Another group of mice was treated in older age, after cataracts had already set in.

(6) This is consistent with the deleterious effect of such cells on tissue function, and with the researchers» conclusion that «the observed improvements in skeletal muscle and fat of late - life treated 10 - month - old BubR1H / H; INK - ATTAC - 5 mice reflect attenuated progression of age - related declines rather than a reversal of ageing».

Relative to both control cohorts of the same age, 9 - 10 mo old treated mice exhibited dramatically more youthful tissues.

For that purpose, 21 - to 23 - month - old mice were treated with daily injections of either recombinant GDF11 (rGDF11, 0.1 mg / kg mouse body weight), a dosing regimen that increases GDF11 levels in old mice toward youthful levels (13), or phosphate - buffered saline (PBS)(vehicle) for 4 weeks, and their blood vessels were subsequently analyzed by using the volumetric assay described above.