Sentences with phrase «treated with gene»

Despite the marginal improvements in survival of patients suffering from malignant glioma treated with gene therapy vectors, the clinical trials conducted so far using viral vectors, in particular adenoviral vectors, have proven that the use of adenoviral vectors is a safe therapeutic approach, even in large, multicenter, phase 3 clinical trials.

«In the group that was not treated with the gene therapy, the majority of the animals die from aplastic anaemia, and they also die much sooner.»

Plaques decreased substantially in mice treated with gene therapy to increase activity of the enzyme neuraminidase 1 (NEU1) in a region of the brain involved in learning and memory.

Researchers found that all 15 children with SMA1 treated with the gene therapy were functioning without any major disability or progression of their disease.

«The T cell leukaemia seen in one of the patients treated with gene therapy for SCID - X1 is extremely regrettable and our sympathies are with the child and his family as he undergoes chemotherapy.

2/12/2008 Gene Therapy Protocol at UCSD Activates Immune System in Patients with Leukemia A research team at the Rebecca and John Moores UCSD Cancer Center at University of California, San Diego (UCSD) reports that patients with chronic lymphocytic leukemia (CLL) who were treated with a gene therapy protocol began making antibodies that r...

Two children treated with gene - edited cells to kill their cancers are both doing well more than a year later.

Before he was treated with the gene therapy, Jake would wake up early before work to inject three times a week as well as injecting whenever he had an injury to stop the bleeding.

Once treated with the gene that increased new neuron population, however, the mice reverted to assessing their new surroundings first, as usual.

Five children with a genetic disease that wipes out their immune system have successfully been treated with gene therapy

SCID was the first condition to be treated with gene therapy more than 20 years ago.

The first people to be treated with a gene therapy had ADA - SCID, also called «bubble boy disease», and some later got leukaemia, probably because the virus carrying the new genes also switched on cancer genes.

«In the group that was not treated with the gene therapy, the majority of the animals die from aplastic anemia, and they also die much sooner.»

One blind group was treated with the gene therapy, while the other two groups were not.

They found that meadow voles treated with gene therapy acted more like their prairie vole counterparts — they spent more time huddling near their original companion.

Although the researchers don't know precisely how the chaperone molecule works, the difference was unmistakable: Less than 40 % of cells treated with gene therapy had clumps, compared to 70 % of controls.

Two of 10 children treated with gene therapy for SCID in a French trial develop leukemia, researchers announced in 2002, and it is discovered that the virus had inserted genes in several unexpected places around the genome, leading the cells to become cancerous.

When the researchers paired female mice treated with the gene therapy with males, the females were still able to become pregnant — and have healthy babies — within the first six weeks, because of those follicles that had already started growing in the ovaries.

Not exact matches

Editas, a startup based in Cambridge and founded in November 2013, wants to eventually use the technology to treat disease by coming up with therapies that can modify faulty disease - causing genes.

Although there has been some recent success in treating disease with gene therapy, these types of procedures are far from perfect and can put a user's health — and life — at risk.

The first gene therapies approved in the United States are treating patients with certain types of leukemia and lymphoma.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Specifically, they have found unnaturally high levels of antibiotic resistance genes in sediments where the river comes into contact with treated municipal wastewater effluent and farm irrigation runoff as it flows 126 miles from Rocky Mountain National Park through Fort Collins and across Colorado's eastern plain, home to some of the country's most densely packed livestock operations.

EXTREME differences in the way genes are expressed by fetuses with Down's syndrome could point to ways to treat the condition in the womb.

Building the knowledge base requires humans to teach computers key concepts from curated articles; with modest online training, anyone who reads English can scan research papers for key terms — names of genes, proteins, diseases, and drugs — and use online marking tools to document relationships between them (for example, drug X treats disease Y).

The survey, described today in a Policy Forum published by Science, randomly presented people with different vignettes that described genome editing being used in germline or somatic cells to either treat disease or enhance a human with, say, a gene linked to higher IQ or eye color.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

These cells have been notoriously difficult to treat with previous gene - delivery techniques.

They are also studying whether the nanoparticles can be used with the CRISPR / Cas9 gene - editing technique to treat genetic lesions related to retinal degenerative diseases.

The researchers assessed LPLD - related acute abdominal events that required hospital care in a small group of patients treated with a single dose of the gene therapy product Glybera ®.

And in an ironic twist, the work could yield a new way to treat common ailments such as heart disease and cancer with gene therapies.

Those with the gene are treated with Herceptin, a drug that we know provides a benefit.

To learn which genes in the mussel make the byssal threads, the researchers first treated the threads with the enzyme pepsin to liquefy their interlocking networks of proteins.

PARP inhibitors are used primarily to treat tumors linked to defects in BRCA genes, but may show promise in other cancers when combined with other drugs.

«Stem cell gene therapy could be key to treating Duchenne muscular dystrophy: Approach developed at UCLA holds promise for 60 percent of patients with the deadly disease.»

Between 2008 and 2011 Jean Bennett, a neuroscientist at the University of Pennsylvania, and her colleagues used gene therapy to treat blindness in 12 adults and children with Leber's congenital amaurosis (LCA).

This tells us how these genes evolved and gives insight on what the genes do and how mutations might be treated with drugs.

A baby's leukemia was successfully treated in 2015 with CAR - T cells engineered with gene editors known as TALENs.

When the group over-expressed the gene for MKP - 1 in the brains of healthy rats, the animals began to show signs of depression which disappeared when treated with an antidepressant (Nature Medicine, DOI: 10.1038 / nm.2219).

In the lab, replacing malfunctioning genes with working ones has succeeded in curing or treating animals with hemophilia, (the animal analogs of) depression, and other afflictions.

Diamond's lab circumvented this problem by creating female mice that had a key interferon gene knocked out; in a second experiment, they treated pregnant animals with an anti-interferon antibody.

2009: A resounding success brings gene therapy back into the limelight: Jean Bennett and Albert Maguire announce that 12 patients with a degenerative disorder leading to total blindness were treated with viruses bearing a replacement gene, and all regain some vision.

Sensory hair cells in the cochlea of a Beethoven mouse treated with TMC2 gene therapy.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

Gene editing could include altering genes in one person — say to treat leukemia in one patient or make a cosmetic change — but, more controversially, it could also include making changes to the germ line that would then alter the genome for an individual's children, grandchildren and the following generations, with potentially unknown repercussions.

Despite much effort, no one has managed to develop an effective form of gene therapy to treat the lung problems of people with cystic fibrosis.

In the study, 50 patients with BRCA gene mutations treated at one of 18 centers took veliparib by mouth twice a day.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

The researchers treated 63 cancer cell lines (26 breast, 14 colorectal and 23 ovarian) with low - dose 5 - azacitidine (AZA), an FDA - approved drug for myelodysplastic syndrome, that reverses epigenetic changes by stripping off the methyl group that silences the gene.

In 2013 another study will focus on a family in Colombia that carries one of these rogue genes, treating them with the amyloid - fighting drug Crenezumab.