Sentences with phrase «treatment against tumor»

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

Not exact matches

Pre-clinical studies have shown that ALT - 803 activates the immune system to mobilize lymphocytes against tumor cells and could potentially serve as an important component in combination treatments.

By releasing the brakes that tumor cells place on the immune system, researchers are developing a new generation of more powerful treatments against malignancy

Drugs That Ramp Up the Immune System against Tumor Cells are Revolutionizing Cancer Treatment

Swanton came up with similar results in three other patients, suggesting that optimum treatment for one region of a tumor might not be effective against another region.

Investigated as a cancer treatment for many years, the molecule didn't turn out to be very effective against tumors, Hale says.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

XL184 inhibits two important treatment escape pathways, VEGF and MET, but while it has FDA approval to treat thyroid cancer and is being tested against pancreatic cancer and several other tumors, it is quite toxic requiring dose restrictions or treatment interruption.

For most available T cell immunotherapies, T cells (which play a central role in defending the body against illness) are engineered to recognize and eliminate tumors, but their activity is not specifically controlled, leading to toxicity and unwanted side effects in patients as a result of inflammation or in some cases suboptimal response to treatment.

Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

While single - agent treatment with either drug had limited effects against mesothelioma, treatment with both drugs significantly reduced tumor size and prolonged the animals» survival.

This is a drawback for a major cancer treatment, immunotherapy, which turns the body's immune system against the tumor.

Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

Now, the two - year, $ 1 million PCF Challenge Award will allow Hsieh and MSK co-primary investigators Dr. Yu Chen and Dr. Brett Carver to combine their expertise to determine which drugs are effective against tumors with specific mutations and identify biomarkers that will enable oncologists to pair prostate cancer patients with the most effective treatment regimens.

Their next steps are to characterize how these treatments affected NK cell function as well as determine the reactivity of patients» T cells against tumor mutations.

These research collaborations have the power to answer questions critical to improving cancer outcomes, such as how tumors develop drug resistance, and what treatments are most effective against particular genomic traits.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

New research into CAR - T cell therapy has revealed crucial mechanisms that could help the immunotherapy technique, which is currently only effective against blood cancers, be adapted for the treatment of brain tumors and other forms of solid cancers.

Dual Approach Better for Liver Cancer A combined treatment for liver cancer that uses one oral drug and another delivered directly to tumors in a method known as chemoembolization appears to work better against liver cancer.

That automation is a clear selling point for Matthew De Silva, whose company, Notable Labs, is trying to devise personalized treatments for brain cancer by testing combinations of thousands of Food and Drug Administration — approved drugs against each individual patient's tumor cells.

According to Lise Alschuler, author of the Definitive Guide To Cancer: An Integrative Approach to Prevention, Treatment, and Healing, studies on flax lignans demonstrate safety and efficacy in their use against breast cancer, «inhibiting the growth of human estrogen - dependent breast cancer cells in mice and strengthening the tumor - inhibitory effect of tamoxifen».

He fought a very hard battle against his brain tumor (glioblastoma multiforme) and finally succumbed to the effects of the treatment.