Sentences with phrase «treatment effects over time»

An important aspect of ITCT - A is its continuous monitoring of treatment effects over time, using the Assessment - Treatment Flowchart (ATF - A).

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

So while there is general agreement that some children do have serious sensory challenges, the disagreement is over whether SPD should be considered an independent disorder, how far sensory issues go in explaining behaviors, and whether the treatment occupational therapists offer for sensory issues has any effect on a child's functioning over time.

«Our results suggest that both the clinical effectiveness and the impressive effects on the quality of life under biological treatment as used in clinical practice are sustained over time.

Computational biology researchers at Pacific Northwest National Laboratory developed a model for predicting what's happening during a stroke, how the process evolves over time, the potential outcomes, and the effects of different treatment options.

Conventional steroid treatments are associated with unpleasant side - effects, and can lose effectiveness over time.

Meals gave significantly different hydrogen profiles over the study period (effect of treatment, P < 0.0001; time × treatment interaction, P < 0.0001).

Meals gave significantly different glucose profiles over the study period (effect of treatment, P < 0.005; time × treatment interaction, P < 0.02).

In the treatment of intestinal protozoan infections... drugs are generally so toxic that they can not be administered for prolonged periods of time, whereas GSE can be administered for weeks or months; prolonged treatment being essential for the cure of chronic protozoan infections... I have had some immunosuppressed patients taking the preparation for over a year with no apparent development of side effects or drug resistance.»

While these treatments won't give your complexion a permanent Benjamin Button effect, they will give you instant gratification unlike a serum or cream, which don't give visible results right away, but do eventually improve texture over time with continued use.

This is because your veterinary medical oncologist will tailor a treatment plan utilizing lower drug doses over a longer period of time to minimize side effects.

Numerous studies have found it to be an effective method for treating trauma ---- treatment effects are maintained over time and fewer sessions are needed to elicit results than for example Cognitive Behavioral Therapy or Exposure Therapy.

Participants were drawn from a larger study examining (i) the effects of trauma on children over time and (ii) the efficacy of the SAFE Homes intervention, a DCF program in which children who have been removed from their parents» care are placed temporarily in state - run facilities rather than immediate foster care to facilitate assessment and treatment planning.

Indeed, Jay Belsky incorporated all of these risk factors into his process model of parenting, 11 and data from multiple studies support links to child well - being.12 In an experiment on the effectiveness of a program for low - birth - weight infants, Lawrence Berger and Jeanne Brooks - Gunn examined the relative effect of both socioeconomic status and parenting on child abuse and neglect (as measured by ratings of health providers who saw children in the treatment and control groups six times over the first three years of life, not by review of administrative data) and found that both factors contributed significantly and uniquely to the likelihood that a family was perceived to engage in some form of child maltreatment.13 The link between parenting behaviors and child maltreatment suggests that interventions that promote positive parenting behaviors would also contribute to lower rates of child maltreatment among families served.

Building on these ideas, we used rich data on selection into and out of neighborhoods to formulate a cross-classified multilevel model designed to estimate causal effects when contextual treatments, outcomes, and confounders all potentially vary over time (32, 33, 48).

For example, higher levels of depression have been shown to be predictive of poorer treatment outcomes for patients with chronic pain, 11 as well as higher health care costs over time.12 Equally, the presence of pain in people being treated for mood disturbance has predicted delayed responses to mood interventions.13 Therefore, improving our understanding of how chronic pain and depression are linked, and treating both components offers the prospect of enhancing treatment effects beyond the benefits of treating either condition alone.14